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7quf

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<StructureSection load='7quf' size='340' side='right'caption='[[7quf]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
<StructureSection load='7quf' size='340' side='right'caption='[[7quf]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[7quf]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7QUF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7QUF FirstGlance]. <br>
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<table><tr><td colspan='2'>[[7quf]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7QUF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7QUF FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=F8I:~{N}-~{tert}-butyl-7,10-dioxa-13,17,18,21-tetrazatetracyclo[12.5.2.1^{2,6}.0^{17,20}]docosa-1(20),2(22),3,5,14(21),15,18-heptaene-5-carboxamide'>F8I</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=F8I:~{N}-~{tert}-butyl-7,10-dioxa-13,17,18,21-tetrazatetracyclo[12.5.2.1^{2,6}.0^{17,20}]docosa-1(20),2(22),3,5,14(21),15,18-heptaene-5-carboxamide'>F8I</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7quf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7quf OCA], [https://pdbe.org/7quf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7quf RCSB], [https://www.ebi.ac.uk/pdbsum/7quf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7quf ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7quf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7quf OCA], [https://pdbe.org/7quf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7quf RCSB], [https://www.ebi.ac.uk/pdbsum/7quf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7quf ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/ST17A_HUMAN ST17A_HUMAN]] Acts as a positive regulator of apoptosis. Also acts as a regulator of cellular reactive oxygen species.<ref>PMID:21489989</ref> <ref>PMID:9786912</ref>
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[https://www.uniprot.org/uniprot/ST17A_HUMAN ST17A_HUMAN] Acts as a positive regulator of apoptosis. Also acts as a regulator of cellular reactive oxygen species.<ref>PMID:21489989</ref> <ref>PMID:9786912</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Non-specific serine/threonine protein kinase]]
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[[Category: Chatterjee D]]
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[[Category: Chatterjee, D]]
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[[Category: Dederer V]]
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[[Category: Dederer, V]]
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[[Category: Hanke T]]
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[[Category: Hanke, T]]
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[[Category: Knapp S]]
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[[Category: Knapp, S]]
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[[Category: Kurz C]]
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[[Category: Kurz, C]]
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[[Category: Mathea S]]
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[[Category: Mathea, S]]
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[[Category: Preuss F]]
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[[Category: Preuss, F]]
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[[Category: Kinase inhibitor small-molecule binder macrocycle]]
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[[Category: Transferase]]
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Current revision

The STK17A (DRAK1) Kinase Domain Bound to CK156

PDB ID 7quf

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