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4abo

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Current revision (10:49, 9 May 2024) (edit) (undo)
 
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<SX load='4abo' size='340' side='right' viewer='molstar' caption='[[4abo]], [[Resolution|resolution]] 8.60&Aring;' scene=''>
<SX load='4abo' size='340' side='right' viewer='molstar' caption='[[4abo]], [[Resolution|resolution]] 8.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4abo]] is a 9 chain structure with sequence from [https://en.wikipedia.org/wiki/Cbs_356 Cbs 356] and [https://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ABO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ABO FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4abo]] is a 9 chain structure with sequence from [https://en.wikipedia.org/wiki/Schizosaccharomyces_pombe Schizosaccharomyces pombe] and [https://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ABO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ABO FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GSP:5-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE'>GSP</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 8.6&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1tub|1tub]], [[1ffx|1ffx]], [[1ia0|1ia0]], [[1jff|1jff]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GSP:5-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE'>GSP</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Tubulin_GTPase Tubulin GTPase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.5.6 3.6.5.6] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4abo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4abo OCA], [https://pdbe.org/4abo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4abo RCSB], [https://www.ebi.ac.uk/pdbsum/4abo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4abo ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4abo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4abo OCA], [https://pdbe.org/4abo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4abo RCSB], [https://www.ebi.ac.uk/pdbsum/4abo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4abo ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/MAL3_SCHPO MAL3_SCHPO]] May play a role in regulating the integrity of microtubules possibly by influencing their stability. Involved in an anchoring mechanism to maintain tea2 and tip1 at growing microtubule ends. Strongly stimulates the ATPase activity of tea2.<ref>PMID:15177031</ref> <ref>PMID:15665379</ref>
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[https://www.uniprot.org/uniprot/TBB_PIG TBB_PIG] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</SX>
</SX>
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[[Category: Cbs 356]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Schizosaccharomyces pombe]]
[[Category: Sus scrofa]]
[[Category: Sus scrofa]]
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[[Category: Tubulin GTPase]]
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[[Category: Bohner G]]
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[[Category: Bohner, G]]
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[[Category: Fourniol FJ]]
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[[Category: Fourniol, F J]]
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[[Category: Maurer SP]]
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[[Category: Maurer, S P]]
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[[Category: Moores CA]]
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[[Category: Moores, C A]]
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[[Category: Surrey T]]
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[[Category: Surrey, T]]
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[[Category: Cytoskeleton]]
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[[Category: End binding]]
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[[Category: Gtpase]]
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[[Category: Structural protein]]
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Current revision

Mal3 CH domain homology model and mammalian tubulin (2XRP) docked into the 8.6-Angstrom cryo-EM map of Mal3-GTPgammaS-microtubules

4abo, resolution 8.60Å

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