4akn

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Current revision (10:51, 9 May 2024) (edit) (undo)
 
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<StructureSection load='4akn' size='340' side='right'caption='[[4akn]], [[Resolution|resolution]] 1.82&Aring;' scene=''>
<StructureSection load='4akn' size='340' side='right'caption='[[4akn]], [[Resolution|resolution]] 1.82&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4akn]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AKN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4AKN FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4akn]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AKN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4AKN FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=S5B:4-[(2-TERT-BUTYLPHENYL)AMINO]-7-(3,5-DIMETHYL-1,2-OXAZOL-4-YL)QUINOLINE-3-CARBOXYLIC+ACID'>S5B</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.82&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1x0j|1x0j]], [[2ydw|2ydw]], [[2yek|2yek]], [[4a9e|4a9e]], [[4a9f|4a9f]], [[4a9h|4a9h]], [[4a9i|4a9i]], [[4a9j|4a9j]], [[4a9m|4a9m]], [[4a9n|4a9n]], [[4a9o|4a9o]], [[4a9p|4a9p]], [[4alg|4alg]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=S5B:4-[(2-TERT-BUTYLPHENYL)AMINO]-7-(3,5-DIMETHYL-1,2-OXAZOL-4-YL)QUINOLINE-3-CARBOXYLIC+ACID'>S5B</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4akn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4akn OCA], [https://pdbe.org/4akn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4akn RCSB], [https://www.ebi.ac.uk/pdbsum/4akn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4akn ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4akn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4akn OCA], [https://pdbe.org/4akn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4akn RCSB], [https://www.ebi.ac.uk/pdbsum/4akn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4akn ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/BRD2_HUMAN BRD2_HUMAN]] May play a role in spermatogenesis or folliculogenesis (By similarity). Binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling. Regulates transcription of the CCND1 gene. Plays a role in nucleosome assembly.<ref>PMID:18406326</ref>
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[https://www.uniprot.org/uniprot/BRD2_HUMAN BRD2_HUMAN] May play a role in spermatogenesis or folliculogenesis (By similarity). Binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling. Regulates transcription of the CCND1 gene. Plays a role in nucleosome assembly.<ref>PMID:18406326</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Bouillot, A]]
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[[Category: Bouillot A]]
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[[Category: Chung, C]]
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[[Category: Chung C]]
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[[Category: Donche, F]]
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[[Category: Donche F]]
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[[Category: Lamotte, Y]]
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[[Category: Lamotte Y]]
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[[Category: Mirguet, O]]
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[[Category: Mirguet O]]
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[[Category: Epigenetic reader]]
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[[Category: Histone]]
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[[Category: Inhibitor]]
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[[Category: Protein binding]]
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Current revision

N-Terminal Bromodomain of Human BRD2 With tbutyl-phenyl-amino- dimethyl-oxazolyl-quinoline-carboxylic acid

PDB ID 4akn

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OCA

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