This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


4aot

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (11:31, 20 December 2023) (edit) (undo)
 
Line 3: Line 3:
<StructureSection load='4aot' size='340' side='right'caption='[[4aot]], [[Resolution|resolution]] 2.33&Aring;' scene=''>
<StructureSection load='4aot' size='340' side='right'caption='[[4aot]], [[Resolution|resolution]] 2.33&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[4aot]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AOT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4AOT FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[4aot]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AOT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4AOT FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GW8:1-(4-{METHYL[2-({4-[(METHYLSULFONYL)METHYL]PHENYL}AMINO)PYRIMIDIN-4-YL]AMINO}PHENYL)-3-{3-[(4-METHYLPIPERAZIN-1-YL)CARBONYL]PHENYL}UREA'>GW8</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.33&#8491;</td></tr>
-
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2j7t|2j7t]], [[3zz2|3zz2]]</div></td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GW8:1-(4-{METHYL[2-({4-[(METHYLSULFONYL)METHYL]PHENYL}AMINO)PYRIMIDIN-4-YL]AMINO}PHENYL)-3-{3-[(4-METHYLPIPERAZIN-1-YL)CARBONYL]PHENYL}UREA'>GW8</scene></td></tr>
-
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">STK10, LOK ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
+
-
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4aot FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4aot OCA], [https://pdbe.org/4aot PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4aot RCSB], [https://www.ebi.ac.uk/pdbsum/4aot PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4aot ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4aot FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4aot OCA], [https://pdbe.org/4aot PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4aot RCSB], [https://www.ebi.ac.uk/pdbsum/4aot PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4aot ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
-
[[https://www.uniprot.org/uniprot/STK10_HUMAN STK10_HUMAN]] The disease may be caused by mutations affecting the gene represented in this entry.<ref>PMID:16175573</ref>
+
[https://www.uniprot.org/uniprot/STK10_HUMAN STK10_HUMAN] The disease may be caused by mutations affecting the gene represented in this entry.<ref>PMID:16175573</ref>
== Function ==
== Function ==
-
[[https://www.uniprot.org/uniprot/STK10_HUMAN STK10_HUMAN]] Serine/threonine-protein kinase involved in regulation of lymphocyte migration. Phosphorylates MSN, and possibly PLK1. Involved in regulation of lymphocyte migration by mediating phosphorylation of ERM proteins such as MSN. Acts as a negative regulator of MAP3K1/MEKK1. May also act as a cell cycle regulator by acting as a polo kinase kinase: mediates phosphorylation of PLK1 in vitro; however such data require additional evidences in vivo.<ref>PMID:11903060</ref> <ref>PMID:12639966</ref> <ref>PMID:19255442</ref>
+
[https://www.uniprot.org/uniprot/STK10_HUMAN STK10_HUMAN] Serine/threonine-protein kinase involved in regulation of lymphocyte migration. Phosphorylates MSN, and possibly PLK1. Involved in regulation of lymphocyte migration by mediating phosphorylation of ERM proteins such as MSN. Acts as a negative regulator of MAP3K1/MEKK1. May also act as a cell cycle regulator by acting as a polo kinase kinase: mediates phosphorylation of PLK1 in vitro; however such data require additional evidences in vivo.<ref>PMID:11903060</ref> <ref>PMID:12639966</ref> <ref>PMID:19255442</ref>
==See Also==
==See Also==
Line 21: Line 19:
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Human]]
+
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
-
[[Category: Non-specific serine/threonine protein kinase]]
+
[[Category: Arrowsmith C]]
-
[[Category: Arrowsmith, C]]
+
[[Category: Bountra C]]
-
[[Category: Bountra, C]]
+
[[Category: Canning P]]
-
[[Category: Canning, P]]
+
[[Category: Edwards A]]
-
[[Category: Delft, F von]]
+
[[Category: Elkins JM]]
-
[[Category: Edwards, A]]
+
[[Category: Knapp S]]
-
[[Category: Elkins, J M]]
+
[[Category: Liu Y]]
-
[[Category: Knapp, S]]
+
[[Category: Salah E]]
-
[[Category: Liu, Y]]
+
[[Category: Szklarz M]]
-
[[Category: Salah, E]]
+
[[Category: Yue W]]
-
[[Category: Szklarz, M]]
+
[[Category: Von Delft F]]
-
[[Category: Yue, W]]
+
-
[[Category: Lok]]
+
-
[[Category: Stk10]]
+
-
[[Category: Transferase]]
+

Current revision

Crystal Structure of Human Serine Threonine Kinase-10 (LOK) Bound to GW830263A

PDB ID 4aot

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4aot"
Personal tools