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Template:STRUCTURE 1i10

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Current revision

1i10, resolution 2.30Å ()

Ligands:

, ,

Gene:

LDHA (Homo sapiens)

Activity:

L-lactate dehydrogenase, with EC number 1.1.1.27

Related:

1i0z, 9ldt, 5ldh, 1ldg

Structural annotation:
Resources:	CATH : 1I10A02, 1I10A01, 1I10B01, 1I10B02, 1I10C02, 1I10C01, 1I10D01, 1I10D02, 1I10E02, 1I10E01, 1I10F01, 1I10F02, 1I10G02, 1I10G01, 1I10H01, 1I10H02 InterPro : Ipr001557, Ipr001236, Ipr011304 Pfam : PF00056, PF02866 SCOP : d1i10a1, d1i10a2, d1i10b2, d1i10b1, d1i10c2, d1i10c1, d1i10d1, d1i10d2, d1i10e1, d1i10e2, d1i10f1, d1i10f2, d1i10g2, d1i10g1, d1i10h2, d1i10h1 UniProt : P00338

Functional annotation:
Cellular component:	cytosol cytoplasm
Biological process:	anaerobic glycolysis cellular carbohydrate metabolic process glycolysis tricarboxylic acid cycle intermediate metabolic process
Molecular function:	L-lactate dehydrogenase activity oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor oxidoreductase activity protein binding

Evolutionary conservation:

Toggle Conservation Colors:	Rows = identical sequences:
Further Information:	Caveats, Explanation, Complete Results at ConSurfDB

Resources:

FirstGlance, OCA, RCSB, PDBsum

Coordinates:

save as pdb, mmCIF, xml

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/Template:STRUCTURE_1i10"

@@ Line 1: / Line 1: @@
 {{Structure
-|PDB= {{{PDB}}}|SCENE={{{SCENE}}}|SIZE=350|CAPTION= 1i10, resolution 2.3&Aring; (<scene name='initialview01'>initial scene</scene>)
+|PDB= {{{PDB}}}|SCENE={{{SCENE|}}}|SIZE={{{SIZE|350}}}|CAPTION={{{CAPTION|[[1i10]], [[Resolution|resolution]] 2.30&Aring; (<scene name='initialview01'>default scene</scene>)}}}
-|SITE=
 |LIGAND= <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=NAI:1,4-DIHYDRONICOTINAMIDE+ADENINE+DINUCLEOTIDE'>NAI</scene>, <scene name='pdbligand=OXM:OXAMIC+ACID'>OXM</scene>
 |ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/L-lactate_dehydrogenase L-lactate dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.27 1.1.1.27] </span>
 |GENE= LDHA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
-|DOMAIN=<span class='plainlinks'>[http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=PRK00066 ldh], [http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00300 LDH]</span>
 |RELATEDENTRY=[[1i0z|1i0z]], [[9ldt|9ldt]], [[5ldh|5ldh]], [[1ldg|1ldg]]
-|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1i10 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1i10 OCA], [http://www.ebi.ac.uk/pdbsum/1i10 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1i10 RCSB]</span>
+|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1i10 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1i10 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1i10 RCSB], [http://www.ebi.ac.uk/pdbsum/1i10 PDBsum]</span>
+|FUNCTION={{GO|id=GO:0004459 | text = L-lactate dehydrogenase activity}}{{GO|id=GO:0016616 | text = oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor}}{{GO|id=GO:0016491 | text = oxidoreductase activity}}{{GO|id=GO:0005515 | text = protein binding}}
+|PROCESS={{GO|id=GO:0019642 | text = anaerobic glycolysis}}{{GO|id=GO:0044262 | text = cellular carbohydrate metabolic process}}{{GO|id=GO:0006096 | text = glycolysis}}{{GO|id=GO:0006100 | text = tricarboxylic acid cycle intermediate metabolic process}}
+|COMPONENT={{GO|id=GO:0005829 | text = cytosol}}{{GO|id=GO:0005737 | text = cytoplasm}}
+|SARESOURCES=<span class='plainlinks'>CATH : [http://www.cathdb.info/cgi-bin/cath/Domain.pl?domain_id=1i10A02 1I10A02], [http://www.cathdb.info/cgi-bin/cath/Domain.pl?domain_id=1i10A01 1I10A01], [http://www.cathdb.info/cgi-bin/cath/Domain.pl?domain_id=1i10B01 1I10B01], [http://www.cathdb.info/cgi-bin/cath/Domain.pl?domain_id=1i10B02 1I10B02], [http://www.cathdb.info/cgi-bin/cath/Domain.pl?domain_id=1i10C02 1I10C02], [http://www.cathdb.info/cgi-bin/cath/Domain.pl?domain_id=1i10C01 1I10C01], [http://www.cathdb.info/cgi-bin/cath/Domain.pl?domain_id=1i10D01 1I10D01], [http://www.cathdb.info/cgi-bin/cath/Domain.pl?domain_id=1i10D02 1I10D02], [http://www.cathdb.info/cgi-bin/cath/Domain.pl?domain_id=1i10E02 1I10E02], [http://www.cathdb.info/cgi-bin/cath/Domain.pl?domain_id=1i10E01 1I10E01], [http://www.cathdb.info/cgi-bin/cath/Domain.pl?domain_id=1i10F01 1I10F01], [http://www.cathdb.info/cgi-bin/cath/Domain.pl?domain_id=1i10F02 1I10F02], [http://www.cathdb.info/cgi-bin/cath/Domain.pl?domain_id=1i10G02 1I10G02], [http://www.cathdb.info/cgi-bin/cath/Domain.pl?domain_id=1i10G01 1I10G01], [http://www.cathdb.info/cgi-bin/cath/Domain.pl?domain_id=1i10H01 1I10H01], [http://www.cathdb.info/cgi-bin/cath/Domain.pl?domain_id=1i10H02 1I10H02]<br>InterPro : [http://www.ebi.ac.uk/interpro/ISearch?query=IPR001557 Ipr001557], [http://www.ebi.ac.uk/interpro/ISearch?query=IPR001236 Ipr001236], [http://www.ebi.ac.uk/interpro/ISearch?query=IPR011304 Ipr011304]<br>Pfam : [http://pfam.sanger.ac.uk/family?acc=PF00056 PF00056], [http://pfam.sanger.ac.uk/family?acc=PF02866 PF02866]<br>SCOP : [http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?search_type=SCOP&amp;key=61499 d1i10a1], [http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?search_type=SCOP&amp;key=61500 d1i10a2], [http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?search_type=SCOP&amp;key=61502 d1i10b2], [http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?search_type=SCOP&amp;key=61501 d1i10b1], [http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?search_type=SCOP&amp;key=61504 d1i10c2], [http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?search_type=SCOP&amp;key=61503 d1i10c1], [http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?search_type=SCOP&amp;key=61505 d1i10d1], [http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?search_type=SCOP&amp;key=61506 d1i10d2], [http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?search_type=SCOP&amp;key=61507 d1i10e1], [http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?search_type=SCOP&amp;key=61508 d1i10e2], [http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?search_type=SCOP&amp;key=61509 d1i10f1], [http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?search_type=SCOP&amp;key=61510 d1i10f2], [http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?search_type=SCOP&amp;key=61512 d1i10g2], [http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?search_type=SCOP&amp;key=61511 d1i10g1], [http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?search_type=SCOP&amp;key=61514 d1i10h2], [http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?search_type=SCOP&amp;key=61513 d1i10h1]<br>UniProt : [http://ca.expasy.org/cgi-bin/niceprot.pl?P00338 P00338]</span>
+|uPDB=1I10|CONSURF={{!}}-
+{{!}} colspan="2" style="background-color:#bac9f7;color:#040d44;vertical-align:top;text-align:left;" {{!}} [[Image:Consurf_key_small.gif|center]]
+{{!}}-{{!}} style="background-color:#bac9f7;color:#040d44;vertical-align:top;text-align:left;"
+{{!}} '''Toggle Conservation Colors:'''
+{{!}} align="left" style="background-color:#acfaac;border-top:2px solid #dddddd; border-right:2px solid #dddddd" {{!}}
+Rows = identical sequences:
+<jmol>
+<jmolButton>
+<script></script>
+<text>A [x]</text>
+<name>jmb_1i10_A</name>
+<title>toggle chain A</title>
+<jsscript>ConsurfChainButton(elementClicked)</jsscript>
+<appendtargetsuffixtoid>true</appendtargetsuffixtoid>
+</jmolButton>
+</jmol>
+<jmol>
+<jmolButton>
+<script></script>
+<text>B [x]</text>
+<name>jmb_1i10_B</name>
+<title>toggle chain B</title>
+<jsscript>ConsurfChainButton(elementClicked)</jsscript>
+<appendtargetsuffixtoid>true</appendtargetsuffixtoid>
+</jmolButton>
+</jmol>
+<jmol>
+<jmolButton>
+<script></script>
+<text>C [x]</text>
+<name>jmb_1i10_C</name>
+<title>toggle chain C</title>
+<jsscript>ConsurfChainButton(elementClicked)</jsscript>
+<appendtargetsuffixtoid>true</appendtargetsuffixtoid>
+</jmolButton>
+</jmol>
+<jmol>
+<jmolButton>
+<script></script>
+<text>D [x]</text>
+<name>jmb_1i10_D</name>
+<title>toggle chain D</title>
+<jsscript>ConsurfChainButton(elementClicked)</jsscript>
+<appendtargetsuffixtoid>true</appendtargetsuffixtoid>
+</jmolButton>
+</jmol>
+<jmol>
+<jmolButton>
+<script></script>
+<text>E [x]</text>
+<name>jmb_1i10_E</name>
+<title>toggle chain E</title>
+<jsscript>ConsurfChainButton(elementClicked)</jsscript>
+<appendtargetsuffixtoid>true</appendtargetsuffixtoid>
+</jmolButton>
+</jmol>
+<jmol>
+<jmolButton>
+<script></script>
+<text>F [x]</text>
+<name>jmb_1i10_F</name>
+<title>toggle chain F</title>
+<jsscript>ConsurfChainButton(elementClicked)</jsscript>
+<appendtargetsuffixtoid>true</appendtargetsuffixtoid>
+</jmolButton>
+</jmol>
+<jmol>
+<jmolButton>
+<script></script>
+<text>G [x]</text>
+<name>jmb_1i10_G</name>
+<title>toggle chain G</title>
+<jsscript>ConsurfChainButton(elementClicked)</jsscript>
+<appendtargetsuffixtoid>true</appendtargetsuffixtoid>
+</jmolButton>
+</jmol>
+<jmol>
+<jmolButton>
+<script></script>
+<text>H [x]</text>
+<name>jmb_1i10_H</name>
+<title>toggle chain H</title>
+<jsscript>ConsurfChainButton(elementClicked)</jsscript>
+<appendtargetsuffixtoid>true</appendtargetsuffixtoid>
+</jmolButton>
+</jmol>
 }}

Template:STRUCTURE 1i10

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