7va1
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of human 3-phosphoglycerate dehydrogenase in complex with GDD-04-35== | |
| + | <StructureSection load='7va1' size='340' side='right'caption='[[7va1]], [[Resolution|resolution]] 1.74Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[7va1]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7VA1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7VA1 FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.74Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5YP:4-[(3-ethanoylphenyl)sulfamoyl]-~{N}-[4-(3-fluorophenyl)-1,3-thiazol-2-yl]benzamide'>5YP</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7va1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7va1 OCA], [https://pdbe.org/7va1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7va1 RCSB], [https://www.ebi.ac.uk/pdbsum/7va1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7va1 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Disease == | ||
| + | [https://www.uniprot.org/uniprot/SERA_HUMAN SERA_HUMAN] Defects in PHGDH are the cause of phosphoglycerate dehydrogenase deficiency (PHGDH deficiency) [MIM:[https://omim.org/entry/601815 601815]. It is characterized by congenital microcephaly, psychomotor retardation, and seizures. | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/SERA_HUMAN SERA_HUMAN] | ||
| - | + | ==See Also== | |
| - | + | *[[Phosphoglycerate dehydrogenase|Phosphoglycerate dehydrogenase]] | |
| - | + | __TOC__ | |
| - | [[Category: | + | </StructureSection> |
| - | [[Category: Cen | + | [[Category: Homo sapiens]] |
| - | [[Category: Gao | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Cen Y]] |
| - | [[Category: | + | [[Category: Gao D]] |
| + | [[Category: Tian P]] | ||
| + | [[Category: Zhou J]] | ||
Current revision
Crystal structure of human 3-phosphoglycerate dehydrogenase in complex with GDD-04-35
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Categories: Homo sapiens | Large Structures | Cen Y | Gao D | Tian P | Zhou J
