This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
8e7m
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 8e7m is ON HOLD Authors: Barnes, C.O. Description: Structure of the human ACE2 receptor in complex with antibody Fab fragment, 05B04 [[Category: Un...) |
|||
| (One intermediate revision not shown.) | |||
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Structure of the human ACE2 receptor in complex with antibody Fab fragment, 05B04== | |
| - | + | <StructureSection load='8e7m' size='340' side='right'caption='[[8e7m]], [[Resolution|resolution]] 3.30Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8e7m]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8E7M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8E7M FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8e7m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8e7m OCA], [https://pdbe.org/8e7m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8e7m RCSB], [https://www.ebi.ac.uk/pdbsum/8e7m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8e7m ProSAT]</span></td></tr> |
| - | [[Category: Barnes | + | </table> |
| + | == Function == | ||
| + | [[https://www.uniprot.org/uniprot/ACE2_HUMAN ACE2_HUMAN]] Carboxypeptidase which converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator. Also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. May be an important regulator of heart function. In case of human coronaviruses SARS and HCoV-NL63 infections, serve as functional receptor for the spike glycoprotein of both coronaviruses.<ref>PMID:10969042</ref> <ref>PMID:10924499</ref> <ref>PMID:14647384</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Barnes CO]] | ||
Current revision
Structure of the human ACE2 receptor in complex with antibody Fab fragment, 05B04
| |||||||||||
