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4b68

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Current revision (11:44, 20 December 2023) (edit) (undo)
 
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<StructureSection load='4b68' size='340' side='right'caption='[[4b68]], [[Resolution|resolution]] 2.29&Aring;' scene=''>
<StructureSection load='4b68' size='340' side='right'caption='[[4b68]], [[Resolution|resolution]] 2.29&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4b68]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Aspfm Aspfm]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B68 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4B68 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4b68]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Aspergillus_fumigatus Aspergillus fumigatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B68 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4B68 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ARG:ARGININE'>ARG</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.29&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[4b63|4b63]], [[4b64|4b64]], [[4b65|4b65]], [[4b66|4b66]], [[4b67|4b67]], [[4b69|4b69]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ARG:ARGININE'>ARG</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4b68 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4b68 OCA], [https://pdbe.org/4b68 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4b68 RCSB], [https://www.ebi.ac.uk/pdbsum/4b68 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4b68 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4b68 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4b68 OCA], [https://pdbe.org/4b68 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4b68 RCSB], [https://www.ebi.ac.uk/pdbsum/4b68 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4b68 ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SIDA_ASPFU SIDA_ASPFU] Catalyzes the conversion of L-ornithine to N(5)-hydroxyornithine, the first step in the biosynthesis of all hydroxamate-containing siderophores, such as the secreted triacetylfusarinine C (TAFC) involved in iron uptake and the intracellular iron storage compound desferriferricrocin (DFFC). Highly specific for its substrate, only hydrolyzing l-ornithine. Has preference for NADPH over NADH, NADPH playing a role in stabilization of the C4a-hydroperoxyflavin intermediate. Essential for virulence.<ref>PMID:15504822</ref> <ref>PMID:16113265</ref> <ref>PMID:20614882</ref> <ref>PMID:22465572</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Aspfm]]
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[[Category: Aspergillus fumigatus]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Fedkenheuer, M]]
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[[Category: Fedkenheuer M]]
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[[Category: Franceschini, S]]
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[[Category: Franceschini S]]
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[[Category: Mattevi, A]]
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[[Category: Mattevi A]]
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[[Category: Robinson, H H]]
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[[Category: Robinson HH]]
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[[Category: Sobrado, P]]
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[[Category: Sobrado P]]
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[[Category: Vogelaar, N J]]
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[[Category: Vogelaar NJ]]
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[[Category: Oxidoreductase]]
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[[Category: Siderophore]]
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Current revision

A. fumigatus ornithine hydroxylase (SidA), re-oxidised state bound to NADP and Arg

PDB ID 4b68

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