4bf4
From Proteopedia
(Difference between revisions)
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<StructureSection load='4bf4' size='340' side='right'caption='[[4bf4]], [[Resolution|resolution]] 2.70Å' scene=''> | <StructureSection load='4bf4' size='340' side='right'caption='[[4bf4]], [[Resolution|resolution]] 2.70Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4bf4]] is a 16 chain structure with sequence from [https://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[4bf4]] is a 16 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_venezuelae Streptomyces venezuelae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BF4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BF4 FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=17Q:1.7.6+5-CYCLODODECYLOXY-N,N-DIMETHYL-PENTAN-1-AMINE'>17Q</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7Å</td></tr> |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=17Q:1.7.6+5-CYCLODODECYLOXY-N,N-DIMETHYL-PENTAN-1-AMINE'>17Q</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4bf4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bf4 OCA], [https://pdbe.org/4bf4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4bf4 RCSB], [https://www.ebi.ac.uk/pdbsum/4bf4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4bf4 ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4bf4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bf4 OCA], [https://pdbe.org/4bf4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4bf4 RCSB], [https://www.ebi.ac.uk/pdbsum/4bf4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4bf4 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/PIKC_STRVZ PIKC_STRVZ] Catalyzes the hydroxylation of narbomycin to give rise to pikromycin, and of 10-deoxymethymycin (YC-17) to give rise to methymycin and neomethymycin during macrolide antibiotic biosynthesis. In addition, produces low amounts of neopicromycin, novapikromycin and novamethymycin. Requires the participation of a ferredoxin and a ferredoxin reductase for the transfer of electrons from NADPH to the monooxygenase.<ref>PMID:16825192</ref> <ref>PMID:19124459</ref> <ref>PMID:19833867</ref> <ref>PMID:24627965</ref> <ref>PMID:9778370</ref> <ref>PMID:9831532</ref> | ||
==See Also== | ==See Also== | ||
*[[Cytochrome P450 hydroxylase 3D structures|Cytochrome P450 hydroxylase 3D structures]] | *[[Cytochrome P450 hydroxylase 3D structures|Cytochrome P450 hydroxylase 3D structures]] | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: As 4 1526]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: | + | [[Category: Streptomyces venezuelae]] |
| - | [[Category: | + | [[Category: Podust LM]] |
| - | + | ||
| - | + | ||
Current revision
PikC D50N mutant in complex with the engineered cycloalkane substrate mimic bearing a termianl N,N-dimethylamino group
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