4bkl

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (11:53, 20 December 2023) (edit) (undo)
 
Line 4: Line 4:
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4bkl]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BKL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BKL FirstGlance]. <br>
<table><tr><td colspan='2'>[[4bkl]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BKL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BKL FirstGlance]. <br>
-
</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=HYP:4-HYDROXYPROLINE'>HYP</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.25&#8491;</td></tr>
 +
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HYP:4-HYDROXYPROLINE'>HYP</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4bkl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bkl OCA], [https://pdbe.org/4bkl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4bkl RCSB], [https://www.ebi.ac.uk/pdbsum/4bkl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4bkl ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4bkl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bkl OCA], [https://pdbe.org/4bkl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4bkl RCSB], [https://www.ebi.ac.uk/pdbsum/4bkl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4bkl ProSAT]</span></td></tr>
</table>
</table>
 +
== Disease ==
 +
[https://www.uniprot.org/uniprot/CO2A1_MOUSE CO2A1_MOUSE] Defects in Col2a1 are the cause of a phenotype resembling human spondyloepiphyseal dysplasia congenita (sedc). Homozygous sedc mice can be identified at birth by their small size and shortened trunk. Adults have shortened noses, dysplastic vertebrae, femora and tibias, and retinoschisis and hearing loss.
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/CO2A1_MOUSE CO2A1_MOUSE] Type II collagen is specific for cartilaginous tissues. It is essential for the normal embryonic development of the skeleton, for linear growth and for the ability of cartilage to resist compressive forces.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
Line 22: Line 27:
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
-
[[Category: Dobritzsch, D]]
+
[[Category: Dobritzsch D]]
-
[[Category: Ekman, D]]
+
[[Category: Ekman D]]
-
[[Category: Foerster, M]]
+
[[Category: Foerster M]]
-
[[Category: Ge, C]]
+
[[Category: Ge C]]
-
[[Category: Holmdahl, R]]
+
[[Category: Holmdahl R]]
-
[[Category: Lindh, I]]
+
[[Category: Lindh I]]
-
[[Category: Raposo, B]]
+
[[Category: Raposo B]]
-
[[Category: Schneider, G]]
+
[[Category: Schneider G]]
-
[[Category: Uysal, H]]
+
[[Category: Uysal H]]
-
[[Category: Antibody]]
+
-
[[Category: Collagen type ii]]
+
-
[[Category: Immune system]]
+
-
[[Category: Rheumatoid arthritis]]
+

Current revision

Crystal structure of the arthritogenic antibody M2139 (Fab fragment) in complex with the triple-helical J1 peptide

PDB ID 4bkl

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4bkl"
Personal tools