4bpc

From Proteopedia

(Difference between revisions)

Current revision

Structure of the Catalytic Domain of Protein Tyrosine Phosphatase Sigma in the Sulfenic Acid Form

Structural highlights

4bpc is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 2.1Å
Ligands:
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

PTPRS_HUMAN Interacts with LAR-interacting protein LIP.1.

Publication Abstract from PubMed

Protein tyrosine phosphatase sigma (PTPsigma) plays a vital role in neural development. The extracellular domain of PTPsigma binds to various proteoglycans, which control the activity of 2 intracellular PTP domains (D1 and D2). To understand the regulatory mechanism of PTPsigma, we carried out structural and biochemical analyses of PTPsigma D1D2. In the crystal structure analysis of a mutant form of D1D2 of PTPsigma, we unexpectedly found that the catalytic cysteine of D1 is oxidized to cysteine sulfenic acid, while that of D2 remained in its reduced form, suggesting that D1 is more sensitive to oxidation than D2. This finding contrasts previous observations on PTPalpha. The cysteine sulfenic acid of D1 was further confirmed by immunoblot and mass spectrometric analyses. The stabilization of the cysteine sulfenic acid in the active site of PTP suggests that the formation of cysteine sulfenic acid may function as a stable intermediate during the redox-regulation of PTPs.

Structure of the catalytic domain of protein tyrosine phosphatase sigma in the sulfenic acid form.,Jeon TJ, Chien PN, Chun HJ, Ryu SE Mol Cells. 2013 May 30. PMID:23820885^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Jeon TJ, Chien PN, Chun HJ, Ryu SE. Structure of the catalytic domain of protein tyrosine phosphatase sigma in the sulfenic acid form. Mol Cells. 2013 May 30. PMID:23820885 doi:10.1007/s10059-013-0033-x

1 Structural highlights
2 Function
3 Publication Abstract from PubMed
4 See Also
5 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4bpc"

@@ Line 3: / Line 3: @@
 <StructureSection load='4bpc' size='340' side='right'caption='[[4bpc]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[4bpc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BPC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BPC FirstGlance]. <br>
+<table><tr><td colspan='2'>[[4bpc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BPC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BPC FirstGlance]. <br>
-</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSO:S-HYDROXYCYSTEINE'>CSO</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
-<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] </span></td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CSO:S-HYDROXYCYSTEINE'>CSO</scene></td></tr>
 <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4bpc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bpc OCA], [https://pdbe.org/4bpc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4bpc RCSB], [https://www.ebi.ac.uk/pdbsum/4bpc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4bpc ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[https://www.uniprot.org/uniprot/PTPRS_HUMAN PTPRS_HUMAN]] Interacts with LAR-interacting protein LIP.1.
+[https://www.uniprot.org/uniprot/PTPRS_HUMAN PTPRS_HUMAN] Interacts with LAR-interacting protein LIP.1.
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
@@ Line 26: / Line 26: @@
 __TOC__
 </StructureSection>
-[[Category: Human]]
+[[Category: Homo sapiens]]
 [[Category: Large Structures]]
-[[Category: Protein-tyrosine-phosphatase]]
+[[Category: Chien PN]]
-[[Category: Chien, P N]]
+[[Category: Chun HJ]]
-[[Category: Chun, H J]]
+[[Category: Jeon TJ]]
-[[Category: Jeon, T J]]
+[[Category: Ryu SE]]
-[[Category: Ryu, S E]]
-[[Category: Hydrolase]]
-[[Category: Proteoglycan]]
-[[Category: Redox regulation]]

4bpc

From Proteopedia

Current revision

Structure of the Catalytic Domain of Protein Tyrosine Phosphatase Sigma in the Sulfenic Acid Form

Structural highlights

Function

Publication Abstract from PubMed

See Also

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

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