7rjm
From Proteopedia
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==Crystal structure of human Bromodomain containing protein 3 (BRD3) in complex with ILF3== | ==Crystal structure of human Bromodomain containing protein 3 (BRD3) in complex with ILF3== | ||
| - | <StructureSection load='7rjm' size='340' side='right'caption='[[7rjm]]' scene=''> | + | <StructureSection load='7rjm' size='340' side='right'caption='[[7rjm]], [[Resolution|resolution]] 2.10Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7RJM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7RJM FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7rjm]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7RJM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7RJM FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7rjm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7rjm OCA], [https://pdbe.org/7rjm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7rjm RCSB], [https://www.ebi.ac.uk/pdbsum/7rjm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7rjm ProSAT]</span></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1Å</td></tr> |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ALY:N(6)-ACETYLLYSINE'>ALY</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7rjm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7rjm OCA], [https://pdbe.org/7rjm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7rjm RCSB], [https://www.ebi.ac.uk/pdbsum/7rjm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7rjm ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Disease == | ||
| + | [https://www.uniprot.org/uniprot/BRD3_HUMAN BRD3_HUMAN] Note=A chromosomal aberration involving BRD3 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;9)(q14;q34) with NUT which produces a BRD3-NUT fusion protein. | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/BRD3_HUMAN BRD3_HUMAN] Binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling and interaction with transcription factors. Regulates transcription by promoting the binding of the transcription factor GATA1 to its targets (By similarity). Regulates transcription of the CCND1 gene.<ref>PMID:18406326</ref> | ||
| + | |||
| + | ==See Also== | ||
| + | *[[Bromodomain-containing protein 3D structures|Bromodomain-containing protein 3D structures]] | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Fedorov E]] | [[Category: Fedorov E]] | ||
[[Category: Ghosh A]] | [[Category: Ghosh A]] | ||
[[Category: Islam K]] | [[Category: Islam K]] | ||
Current revision
Crystal structure of human Bromodomain containing protein 3 (BRD3) in complex with ILF3
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