Alpha-synuclein

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<StructureSection load='6flt' size='340' side='right' caption='Human alpha-synuclein (PDB [[6flt]])' scene='84/840509/Cv/1'>
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<StructureSection load='6h6b' size='340' side='right' caption='Human alpha-synuclein (PDB [[6h6b]])' scene='84/840509/Cv/1'>
== Function ==
== Function ==
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The Syn structure shows <scene name='84/840509/Cv/2'>8 β-sheet</scene> forming segments interrupted by <scene name='84/840509/Cv/4'>Gly residues</scene>. Seven PD-associated familial <scene name='84/840509/Cv/5'>mutations</scene> are known. The 3D structure shows a <scene name='84/840509/Cv/6'>hydrophobic cleft</scene> which can provide an entry point for an incoming Syn molecule elongating the fibril<ref>PMID:29969391</ref>.
The Syn structure shows <scene name='84/840509/Cv/2'>8 β-sheet</scene> forming segments interrupted by <scene name='84/840509/Cv/4'>Gly residues</scene>. Seven PD-associated familial <scene name='84/840509/Cv/5'>mutations</scene> are known. The 3D structure shows a <scene name='84/840509/Cv/6'>hydrophobic cleft</scene> which can provide an entry point for an incoming Syn molecule elongating the fibril<ref>PMID:29969391</ref>.
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</StructureSection>
 
== 3D Structures of alpha-synuclein==
== 3D Structures of alpha-synuclein==
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[[Alpha-synuclein 3D structures]]
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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[[6flt]], [[6h6b]], [[6a6b]], [[6cu7]], [[6cu8]], [[6l1t]], [[6l1u]], [[6l4s]], [[6lrq]],[[6rt0]], [[6rtb]], [[6sst]], [[6ssx]], [[6xyo]], [[6xyp]], [[6xyq]], [[6osj]], [[6osl]], [[6osm]], [[7c1d]], [[7l7h]], [[7nca]], [[7ncg]], [[7nch]], [[7nci]], [[7ncj]], [[7nck]], [[7ozg]], [[7ozh]], [[7v47]], [[7v48]], [[7v4a]], [[7v4b]], [[7v4c]], [[7v4d]], [[8a4l]] – hSyn – human - Cryo EM<br />
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[[2n0a]] – hSyn – NMR<br />
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[[6ufr]], [[6peo]], [[6pes]], [[7e0f]] – hSyn (mutant) - Cryo EM<br />
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[[7lc9]] – hSyn 41-140 - Cryo EM<br />
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[[8a9l]] – hSyn + peptide - Cryo EM<br />
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[[7stx]] – hSyn + acetyltransferase + CoA - Cryo EM<br />
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[[2m55]] – hSyn residues 1-19 + calmodulin – NMR<br />
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[[6i42]] – hSyn residues 48-60 + cyclophilin A<br />
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[[5crw]] – hSyn residues 31-41 + protein disulfide isomerase<br />
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[[6ct7]] – hSyn residues 1-10 + antibody<br />
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[[2x6m]] – hSyn residues 132-140 + antibody<br />
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[[3q25]], [[3q26]], [[3q27]], [[3q28]], [[3q29]] – hSyn peptide/MBP<br />
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[[3q26]] – hSyn residues 10-42/MBP<br />
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[[4r0u]], [[4r0w]], [[4rik]], [[4ril]] - hSyn amyloid-forming peptide<br />
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[[4znn]] - hSyn amyloid-forming peptide (mutant)<br />
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== References ==
== References ==
<references/>
<references/>
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</StructureSection>
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

Human alpha-synuclein (PDB 6h6b)

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Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Joel L. Sussman, Alexander Berchansky

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