Aminoacyl tRNA synthetase 3D structures

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* ''Gln-RS ternary complex''
* ''Gln-RS ternary complex''
 +
**[[1euq]], [[1euy]] – EcGlnRS + Gln-tRNA + Gln-SA<br />
**[[1euq]], [[1euy]] – EcGlnRS + Gln-tRNA + Gln-SA<br />
**[[1exd]] - EcGlnRS + Gln-tRNA (mutant) + AMP<br />
**[[1exd]] - EcGlnRS + Gln-tRNA (mutant) + AMP<br />
Line 83: Line 84:
* ''Glu-RS + small substrates or analogs''
* ''Glu-RS + small substrates or analogs''
 +
**[[3afh]] - TmGluRS + Glu-AMP analog<br />
**[[3afh]] - TmGluRS + Glu-AMP analog<br />
**[[2rd2]], [[2re8]] – EcGluRS (mutant) + Glu-SA<br />
**[[2rd2]], [[2re8]] – EcGluRS (mutant) + Glu-SA<br />
Line 94: Line 96:
* ''Glu-RS + tRNA''
* ''Glu-RS + tRNA''
 +
**[[1zjw]] – EcGluRS + Glu-tRNA<br />
**[[1zjw]] – EcGluRS + Glu-tRNA<br />
**[[1g59]] – TtGluRS + Glu-tRNA<br />
**[[1g59]] – TtGluRS + Glu-tRNA<br />
* ''Glu-RS ternary complex''
* ''Glu-RS ternary complex''
 +
**[[5bmu]] – hGluRS GST-like domain + EPRS-AIMP3 <br />
**[[5bmu]] – hGluRS GST-like domain + EPRS-AIMP3 <br />
**[[2hrk]], [[2hsm]] - yGluRS N-terminal + GU4 nucleic-binding protein 1<br />
**[[2hrk]], [[2hsm]] - yGluRS N-terminal + GU4 nucleic-binding protein 1<br />
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* ''Ile-RS + small substrates or analogs''
* ''Ile-RS + small substrates or analogs''
 +
**[[1ue0]] - TtIleRS editing domain + Val<br />
**[[1ue0]] - TtIleRS editing domain + Val<br />
**[[1wnz]] - TtIleS editing domain + Val-adenylate<br />
**[[1wnz]] - TtIleS editing domain + Val-adenylate<br />
Line 120: Line 125:
* ''Ile-RS ternary complex''
* ''Ile-RS ternary complex''
 +
**[[1ffy]], [[1qu2]], [[1qu3]] - SaIleRS + Ile-tRNA + antibiotic - ''Staphylococcus aureus''<br />
**[[1ffy]], [[1qu2]], [[1qu3]] - SaIleRS + Ile-tRNA + antibiotic - ''Staphylococcus aureus''<br />
**[[6ldk]] - CaIleRS + AMP + Ile – ''Candida albicans''<br />
**[[6ldk]] - CaIleRS + AMP + Ile – ''Candida albicans''<br />
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* ''Leu-RS + small substrates or analogs''
* ''Leu-RS + small substrates or analogs''
 +
**[[6kqy]] - hLeuRS + Leu<br />
**[[6kqy]] - hLeuRS + Leu<br />
**[[7d5c]] - yLeuRS + inhibitor<br />
**[[7d5c]] - yLeuRS + inhibitor<br />
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* ''Leu-RS + tRNA''
* ''Leu-RS + tRNA''
 +
**[[1wz2]] – PhLeuRS + Leu-tRNA<br />
**[[1wz2]] – PhLeuRS + Leu-tRNA<br />
**[[5ah5]] - LeuRS + Leu-tRNA – ''Agrobacterium radiobacter''<br >
**[[5ah5]] - LeuRS + Leu-tRNA – ''Agrobacterium radiobacter''<br >
* ''Leu-RS ternary complex''
* ''Leu-RS ternary complex''
 +
**[[6kie]], [[6kr7]] - hLeuRS + Leu-SA + Leu<br />
**[[6kie]], [[6kr7]] - hLeuRS + Leu-SA + Leu<br />
**[[6lpf]], [[6lr6]] - hLeuRS + Leu-SA + adenosine derivative<br />
**[[6lpf]], [[6lr6]] - hLeuRS + Leu-SA + adenosine derivative<br />
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* ''Met-RS + small substrates or analogs''
* ''Met-RS + small substrates or analogs''
 +
**[[5goy]] – hMetRS residues 221-834 + Met<br />
**[[5goy]] – hMetRS residues 221-834 + Met<br />
**[[3kfl]] – LmMetRS residues 206-747+ Met-adenylate - ''Leishmania major''<br />
**[[3kfl]] – LmMetRS residues 206-747+ Met-adenylate - ''Leishmania major''<br />
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* ''Trp-RS + small substrates or analogs''
* ''Trp-RS + small substrates or analogs''
 +
**[[5ujj]] – hTrpRS + Trp-AMP<br />
**[[5ujj]] – hTrpRS + Trp-AMP<br />
**[[2quh]] – hTrpRS + Trp<br />
**[[2quh]] – hTrpRS + Trp<br />
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* ''Trp-RS + tRNA''
* ''Trp-RS + tRNA''
 +
**[[2ake]], [[2dr2]] - hTrpRS + Trp-tRNA<br />
**[[2ake]], [[2dr2]] - hTrpRS + Trp-tRNA<br />
**[[2azx]] – hTrpRS (mutant) + tRNA<br />
**[[2azx]] – hTrpRS (mutant) + tRNA<br />
Line 378: Line 390:
* ''Tyr-RS + small substrates or analogs''
* ''Tyr-RS + small substrates or analogs''
 +
**[[1q11]] – hTyrRS residues 1-364 + Tyr-ol<br />
**[[1q11]] – hTyrRS residues 1-364 + Tyr-ol<br />
**[[2pid]] – hTyrRS residues 28-375 + Tyr-SA<br />
**[[2pid]] – hTyrRS residues 28-375 + Tyr-SA<br />
Line 482: Line 495:
* ''Asp-RS + small substrates or analogs''
* ''Asp-RS + small substrates or analogs''
 +
**[[3nel]] – TkAspRS + Asp<br />
**[[3nel]] – TkAspRS + Asp<br />
**[[3nem]] - TkAspRS + Asp-adenylate<br />
**[[3nem]] - TkAspRS + Asp-adenylate<br />
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* ''Asn-RS + small substrates or analogs''
* ''Asn-RS + small substrates or analogs''
 +
**[[2xti]] – BmAsnRS catalytic fragment + Asn-adenine analog<br />
**[[2xti]] – BmAsnRS catalytic fragment + Asn-adenine analog<br />
**[[2xgt]] - BmAsnRS catalytic fragment + Asn-SA<br />
**[[2xgt]] - BmAsnRS catalytic fragment + Asn-SA<br />
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* ''Gly-RS + small substrates or analogs''
* ''Gly-RS + small substrates or analogs''
 +
**[[2zt5]], [[2zxf]] – hGlyRS residues 55-739 + bis-adenosine tetraphosphate<br />
**[[2zt5]], [[2zxf]] – hGlyRS residues 55-739 + bis-adenosine tetraphosphate<br />
**[[2zt6]] - hGlyRS residues 55-739 + AMPCPP<br />
**[[2zt6]] - hGlyRS residues 55-739 + AMPCPP<br />
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* ''His-RS + small substrates or analogs''
* ''His-RS + small substrates or analogs''
 +
**[[4phc]] - hHisRS + His <br />
**[[4phc]] - hHisRS + His <br />
**[[3lc0]] – TcHisRS residues 45-478 + His – ''Trypanosoma cruzi''<br />
**[[3lc0]] – TcHisRS residues 45-478 + His – ''Trypanosoma cruzi''<br />
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* ''Phe-RS + small substrates or analogs''
* ''Phe-RS + small substrates or analogs''
 +
**[[3hfv]] – hPheRS + Tyr<br />
**[[3hfv]] – hPheRS + Tyr<br />
**[[3teg]] – hPheRS + L-DOPA<br />
**[[3teg]] – hPheRS + L-DOPA<br />
Line 608: Line 626:
* ''Phe-RS + tRNA''
* ''Phe-RS + tRNA''
 +
**[[3tup]] – hPheRS + Phe-tRNA<br />
**[[3tup]] – hPheRS + Phe-tRNA<br />
**[[1eiy]] - TtPheRS α+β chains + Phe-tRNA<br />
**[[1eiy]] - TtPheRS α+β chains + Phe-tRNA<br />
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* ''Pro-RS + small substrates or analogs''
* ''Pro-RS + small substrates or analogs''
 +
**[[3ial]] – GlProRS residues 34-542 + Pro-adenylate<br />
**[[3ial]] – GlProRS residues 34-542 + Pro-adenylate<br />
**[[2i4m]], [[2i4n]] – RpProRS + aa-SA<br />
**[[2i4m]], [[2i4n]] – RpProRS + aa-SA<br />
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*''Pro-RS ternary complex''
*''Pro-RS ternary complex''
 +
**[[4k87]] – hProRS residues 1000-1512 + proline + adenosine<br />
**[[4k87]] – hProRS residues 1000-1512 + proline + adenosine<br />
**[[4k88]] – hProRS residues 1000-1512 + halofunginone<br />
**[[4k88]] – hProRS residues 1000-1512 + halofunginone<br />
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**[[5vad]] – hGlu/ProRS residues 1003-1513 + inhibitor<br />
**[[5vad]] – hGlu/ProRS residues 1003-1513 + inhibitor<br />
**[[7osy]] – hGlu/ProRS residues 1003-1513 + Pro<br />
**[[7osy]] – hGlu/ProRS residues 1003-1513 + Pro<br />
-
**[[7bbu]], [[7f99]], [[7f9c]], [[7osz]], [[7ot0]], [[7ot1]], [[7ot2]], [[7ot3]] – hGlu/ProRS residues 1003-1513 + inhibitor + Pro<br />
+
**[[7bbu]], [[7f98]], [[7f99]], [[7f9a]], [[7f9b]], [[7f9c]], [[7f9d]], [[7osz]], [[7ot0]], [[7ot1]], [[7ot2]], [[7ot3]] – hGlu/ProRS residues 1003-1513 + inhibitor + Pro<br />
-
**[[5a1n]], [[5a34]], [[5a5h]] – hGlu/ProRS GST-like domain + EPRS-AIMP2<br />
+
**[[7x09]], [[7x1o]] – hGlu/ProRS residues 1003-1513 + inhibitor + halofuginone<br />
 +
**[[7y1w]], [[7y28]], [[7y3s]] – hGlu/ProRS residues 1003-1513 + inhibitor + ATP<br />
 +
**[[5a1n]], [[5a34]], [[5a5h]] – hGlu/ProRS GST-like domain 1-175 + EPRS-AIMP2<br />
**[[1fyj]] – hGlu/ProRS 677-733 – NMR<br />
**[[1fyj]] – hGlu/ProRS 677-733 – NMR<br />

Current revision

3D Structures of Aminoacyl tRNA Synthetase

Updated on 24-September-2024

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Joel L. Sussman

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