8dgc

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (06:08, 14 May 2025) (edit) (undo)
 
(One intermediate revision not shown.)
Line 4: Line 4:
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[8dgc]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_phage_PhiV-1 Escherichia phage PhiV-1] and [https://en.wikipedia.org/wiki/Salmonella_enterica Salmonella enterica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8DGC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8DGC FirstGlance]. <br>
<table><tr><td colspan='2'>[[8dgc]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_phage_PhiV-1 Escherichia phage PhiV-1] and [https://en.wikipedia.org/wiki/Salmonella_enterica Salmonella enterica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8DGC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8DGC FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.4&#8491;</td></tr>
 +
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8dgc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8dgc OCA], [https://pdbe.org/8dgc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8dgc RCSB], [https://www.ebi.ac.uk/pdbsum/8dgc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8dgc ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8dgc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8dgc OCA], [https://pdbe.org/8dgc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8dgc RCSB], [https://www.ebi.ac.uk/pdbsum/8dgc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8dgc ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
-
[[https://www.uniprot.org/uniprot/A0A7G3WWS0_9CAUD A0A7G3WWS0_9CAUD]] The terminase large subunit acts as an ATP driven molecular motor necessary for viral DNA translocation into empty capsids and as an endonuclease that cuts the viral genome at a unique and precise dsDNA sequence to initiate and to end a packaging reaction. The terminase lies at a unique vertex of the procapsid and is composed of two subunits, a small terminase subunit involved in viral DNA recognition (packaging sequence), and a large terminase subunit possessing endonucleolytic and ATPase activities. Both terminase subunits heterooligomerize and are docked on the portal protein to form the packaging machine. The terminase large subunit exhibits endonuclease activity and cleaves the viral genome concatemer. Once the DNA is packaged, the terminase detaches from the portal and gets replaced by the tail to finish maturation of the virion.[HAMAP-Rule:MF_04147]
+
[https://www.uniprot.org/uniprot/A0A7G3WWS0_9CAUD A0A7G3WWS0_9CAUD] The terminase large subunit acts as an ATP driven molecular motor necessary for viral DNA translocation into empty capsids and as an endonuclease that cuts the viral genome at a unique and precise dsDNA sequence to initiate and to end a packaging reaction. The terminase lies at a unique vertex of the procapsid and is composed of two subunits, a small terminase subunit involved in viral DNA recognition (packaging sequence), and a large terminase subunit possessing endonucleolytic and ATPase activities. Both terminase subunits heterooligomerize and are docked on the portal protein to form the packaging machine. The terminase large subunit exhibits endonuclease activity and cleaves the viral genome concatemer. Once the DNA is packaged, the terminase detaches from the portal and gets replaced by the tail to finish maturation of the virion.[HAMAP-Rule:MF_04147]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
Line 18: Line 19:
</div>
</div>
<div class="pdbe-citations 8dgc" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 8dgc" style="background-color:#fffaf0;"></div>
 +
 +
==See Also==
 +
*[[Terminase 3D Structures|Terminase 3D Structures]]
== References ==
== References ==
<references/>
<references/>

Current revision

Avs3 bound to phage PhiV-1 terminase

PDB ID 8dgc

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/8dgc"
Personal tools