7y18
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of ribosomal ITS2 pre-rRNA processing complex from Saccharomyces cerevisiae== | |
| - | + | <StructureSection load='7y18' size='340' side='right'caption='[[7y18]], [[Resolution|resolution]] 3.69Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[7y18]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7Y18 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7Y18 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.69Å</td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7y18 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7y18 OCA], [https://pdbe.org/7y18 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7y18 RCSB], [https://www.ebi.ac.uk/pdbsum/7y18 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7y18 ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/GRC3_YEAST GRC3_YEAST] Polynucleotide 5'-kinase involved in rRNA processing. Required for the efficient termination by RNA polymerase I and the processing of the IST2 pre-rRNA internal transcribed spacer localized between the 5.8S and 25S rRNAs. May act by maintaining the phosphorylated status of the downstream RNT1 cleavage product, which in turn allows the torpedo activity of RAT1 to efficiently terminate Pol I transcription. In vitro, displays polynucleotide kinase activity on both single- and double-stranded RNA and on single-stranded DNA alone, but not double-stranded DNA alone.<ref>PMID:12837249</ref> <ref>PMID:20814424</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Saccharomyces cerevisiae S288C]] | ||
| + | [[Category: Chen J]] | ||
| + | [[Category: Liu L]] | ||
Current revision
Crystal structure of ribosomal ITS2 pre-rRNA processing complex from Saccharomyces cerevisiae
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