7b5g
From Proteopedia
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[7b5g]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12] and [https://en.wikipedia.org/wiki/Lama_glama Lama glama]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7B5G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7B5G FirstGlance]. <br> | <table><tr><td colspan='2'>[[7b5g]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12] and [https://en.wikipedia.org/wiki/Lama_glama Lama glama]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7B5G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7B5G FirstGlance]. <br> | ||
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4Å</td></tr> |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7b5g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7b5g OCA], [https://pdbe.org/7b5g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7b5g RCSB], [https://www.ebi.ac.uk/pdbsum/7b5g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7b5g ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7b5g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7b5g OCA], [https://pdbe.org/7b5g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7b5g RCSB], [https://www.ebi.ac.uk/pdbsum/7b5g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7b5g ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| - | + | [https://www.uniprot.org/uniprot/LEXA_ECOLI LEXA_ECOLI] Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. Binds to the 16 bp palindromic sequence 5'-CTGTATATATATACAG-3'. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.<ref>PMID:7027255</ref> <ref>PMID:7027256</ref> | |
== References == | == References == | ||
<references/> | <references/> | ||
Current revision
Crystal structure of E.coli LexA in complex with nanobody NbSOS3(Nb14527)
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Categories: Escherichia coli K-12 | Lama glama | Large Structures | Angelini A | Cendron L | Chinellato M | Maso L | Pardon E | Steyaert J | Tondi D | Vascon F
