7vf2

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== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[7vf2]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7VF2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7VF2 FirstGlance]. <br>
<table><tr><td colspan='2'>[[7vf2]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7VF2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7VF2 FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7vf2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7vf2 OCA], [https://pdbe.org/7vf2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7vf2 RCSB], [https://www.ebi.ac.uk/pdbsum/7vf2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7vf2 ProSAT]</span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7vf2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7vf2 OCA], [https://pdbe.org/7vf2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7vf2 RCSB], [https://www.ebi.ac.uk/pdbsum/7vf2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7vf2 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/VIR_HUMAN VIR_HUMAN]] Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:24981863, PubMed:29507755). Acts as a key regulator of m6A methylation by promoting m6A methylation of mRNAs in the 3'-UTR near the stop codon: recruits the catalytic core components METTL3 and METTL14, thereby guiding m6A methylation at specific sites (PubMed:29507755). Required for mRNA polyadenylation via its role in selective m6A methylation: m6A methylation of mRNAs in the 3'-UTR near the stop codon correlating with alternative polyadenylation (APA) (PubMed:29507755).<ref>PMID:24981863</ref> <ref>PMID:29507755</ref>
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[https://www.uniprot.org/uniprot/VIR_HUMAN VIR_HUMAN] Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:24981863, PubMed:29507755). Acts as a key regulator of m6A methylation by promoting m6A methylation of mRNAs in the 3'-UTR near the stop codon: recruits the catalytic core components METTL3 and METTL14, thereby guiding m6A methylation at specific sites (PubMed:29507755). Required for mRNA polyadenylation via its role in selective m6A methylation: m6A methylation of mRNAs in the 3'-UTR near the stop codon correlating with alternative polyadenylation (APA) (PubMed:29507755).<ref>PMID:24981863</ref> <ref>PMID:29507755</ref>
== References ==
== References ==
<references/>
<references/>

Current revision

Human m6A-METTL associated complex (WTAP, VIRMA, ZC3H13, and HAKAI)

PDB ID 7vf2

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