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From Proteopedia
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== Function == | == Function == | ||
| - | + | [https://www.uniprot.org/uniprot/VIR_HUMAN VIR_HUMAN] Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:24981863, PubMed:29507755). Acts as a key regulator of m6A methylation by promoting m6A methylation of mRNAs in the 3'-UTR near the stop codon: recruits the catalytic core components METTL3 and METTL14, thereby guiding m6A methylation at specific sites (PubMed:29507755). Required for mRNA polyadenylation via its role in selective m6A methylation: m6A methylation of mRNAs in the 3'-UTR near the stop codon correlating with alternative polyadenylation (APA) (PubMed:29507755).<ref>PMID:24981863</ref> <ref>PMID:29507755</ref> | |
== References == | == References == | ||
<references/> | <references/> | ||
Current revision
Human m6A-METTL associated complex (WTAP, VIRMA, and HAKAI)
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Categories: Homo sapiens | Large Structures | Deng T | Gao M | Li S | Liu J | Ma J | Peng C | Su S | Wu B | Yin Y | Zhang K
