8d5p
From Proteopedia
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[8d5p]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8D5P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8D5P FirstGlance]. <br> | <table><tr><td colspan='2'>[[8d5p]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8D5P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8D5P FirstGlance]. <br> | ||
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8d5p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8d5p OCA], [https://pdbe.org/8d5p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8d5p RCSB], [https://www.ebi.ac.uk/pdbsum/8d5p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8d5p ProSAT]</span></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.75Å</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8d5p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8d5p OCA], [https://pdbe.org/8d5p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8d5p RCSB], [https://www.ebi.ac.uk/pdbsum/8d5p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8d5p ProSAT]</span></td></tr> | ||
</table> | </table> | ||
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Certain CD8 T cell responses are particularly effective at controlling infection, as exemplified by elite control of HIV in individuals harboring HLA-B57. To understand the structural features that contribute to CD8 T cell elite control, we focused on a strongly protective CD8 T cell response directed against a parasite-derived peptide (HF10) presented by an atypical MHC-I molecule, H-2Ld. This response exhibits a focused TCR repertoire dominated by Vbeta2, and a representative TCR (TG6) in complex with Ld-HF10 reveals an unusual structure in which both MHC and TCR contribute extensively to peptide specificity, along with a parallel footprint of TCR on its pMHC ligand. The parallel footprint is a common feature of Vbeta2-containing TCRs and correlates with an unusual Valpha-Vbeta interface, CDR loop conformations, and Vbeta2-specific germline contacts with peptides. Vbeta2 and Ld may represent "specialist" components for antigen recognition that allows for particularly strong and focused T cell responses. | Certain CD8 T cell responses are particularly effective at controlling infection, as exemplified by elite control of HIV in individuals harboring HLA-B57. To understand the structural features that contribute to CD8 T cell elite control, we focused on a strongly protective CD8 T cell response directed against a parasite-derived peptide (HF10) presented by an atypical MHC-I molecule, H-2Ld. This response exhibits a focused TCR repertoire dominated by Vbeta2, and a representative TCR (TG6) in complex with Ld-HF10 reveals an unusual structure in which both MHC and TCR contribute extensively to peptide specificity, along with a parallel footprint of TCR on its pMHC ligand. The parallel footprint is a common feature of Vbeta2-containing TCRs and correlates with an unusual Valpha-Vbeta interface, CDR loop conformations, and Vbeta2-specific germline contacts with peptides. Vbeta2 and Ld may represent "specialist" components for antigen recognition that allows for particularly strong and focused T cell responses. | ||
| - | Peptide Centric Vbeta Specific Germline Contacts Shape a Specialist T Cell Response.,Wang Y, Tsitsiklis A, Devoe S, Gao W, Chu HH, Zhang Y, Li W, Wong WK, Deane CM, Neau D, Slansky JE, Thomas PG, Robey EA, Dai S Front Immunol. 2022 Jul 29;13:847092. doi: 10.3389/fimmu.2022.847092. eCollection, 2022. PMID:35967379<ref>PMID:35967379</ref> | + | Peptide Centric Vbeta Specific Germline Contacts Shape a Specialist T Cell Response.,Wang Y, Tsitsiklis A, Devoe S, Gao W, Chu HH, Zhang Y, Li W, Wong WK, Deane CM, Neau D, Slansky JE, Thomas PG, Robey EA, Dai S Front Immunol. 2022 Jul 29;13:847092. doi: 10.3389/fimmu.2022.847092. eCollection , 2022. PMID:35967379<ref>PMID:35967379</ref> |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
Current revision
Mouse TCR TG6
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