1gkg

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(New page: 200px<br /> <applet load="1gkg" size="450" color="white" frame="true" align="right" spinBox="true" caption="1gkg" /> '''STRUCTURE DETERMINATION AND RATIONAL MUTAGE...)
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[[Image:1gkg.gif|left|200px]]<br />
 
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<applet load="1gkg" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1gkg" />
 
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'''STRUCTURE DETERMINATION AND RATIONAL MUTAGENESIS REVEAL BINDING SURFACE OF IMMUNE ADHERENCE RECEPTOR, CR1 (CD35)'''<br />
 
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==Overview==
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==Structure Determination and Rational Mutagenesis reveal binding surface of immune adherence receptor, CR1 (CD35)==
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Complement receptor type 1 (CR1 or CD35) is a multiple modular protein, that mediates the immune adherence phenomenon, a fundamental event for, destroying microbes and initiating an immunological response. It fulfills, this role through binding C3b/C4b-opsonized foreign antigens. The, structure of the principal C3b/C4b binding site (residues 901-1095) of CR1, is reported, revealing three complement control protein modules (modules, 15-17) in an extended head-to-tail arrangement with flexibility at the, 16-17 junction. Structure-guided mutagenesis identified a positively, charged surface region on module 15 that is critical for C4b binding. This, patch, together with basic side chains of module 16 exposed on the same, face of CR1, is required for C3b binding. These studies reveal the initial, structural details of one of the first receptor-ligand interactions to be, identified in immunobiology.
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<StructureSection load='1gkg' size='340' side='right'caption='[[1gkg]]' scene=''>
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== Structural highlights ==
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==Disease==
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<table><tr><td colspan='2'>[[1gkg]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GKG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1GKG FirstGlance]. <br>
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Known diseases associated with this structure: Blood group, Knops system OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=120620 120620]], CR1 deficiency OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=120620 120620]], Malaria, severe, resistance to OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=120620 120620]], SLE susceptibility OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=120620 120620]]
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1gkg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gkg OCA], [https://pdbe.org/1gkg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1gkg RCSB], [https://www.ebi.ac.uk/pdbsum/1gkg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1gkg ProSAT]</span></td></tr>
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==About this Structure==
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</table>
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1GKG is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1GKG OCA].
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== Function ==
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[https://www.uniprot.org/uniprot/CR1_HUMAN CR1_HUMAN] Mediates cellular binding of particles and immune complexes that have activated complement.
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==Reference==
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== Evolutionary Conservation ==
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Structure of the C3b binding site of CR1 (CD35), the immune adherence receptor., Smith BO, Mallin RL, Krych-Goldberg M, Wang X, Hauhart RE, Bromek K, Uhrin D, Atkinson JP, Barlow PN, Cell. 2002 Mar 22;108(6):769-80. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11955431 11955431]
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gk/1gkg_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1gkg ConSurf].
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<div style="clear:both"></div>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Atkinson, J.P.]]
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[[Category: Atkinson JP]]
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[[Category: Barlow, P.N.]]
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[[Category: Barlow PN]]
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[[Category: Bromek, K.]]
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[[Category: Bromek K]]
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[[Category: Hauhart, R.E.]]
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[[Category: Hauhart RE]]
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[[Category: Krych-Goldberg, M.]]
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[[Category: Krych-Goldberg M]]
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[[Category: Mallin, R.L.]]
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[[Category: Mallin RL]]
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[[Category: Smith, B.O.]]
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[[Category: Smith BO]]
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[[Category: Uhrin, D.]]
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[[Category: Uhrin D]]
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[[Category: Wang, X.]]
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[[Category: Wang X]]
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[[Category: complement]]
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[[Category: module]]
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[[Category: scr]]
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[[Category: structure]]
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[[Category: sushi]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 17:06:42 2007''
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Current revision

Structure Determination and Rational Mutagenesis reveal binding surface of immune adherence receptor, CR1 (CD35)

PDB ID 1gkg

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