4cv8
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4cv8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CV8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4CV8 FirstGlance]. <br> | <table><tr><td colspan='2'>[[4cv8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CV8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4CV8 FirstGlance]. <br> | ||
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3D7:3-AMINO-5-(1-METHYL-1H-PYRAZOL-4-YL)PYRIDIN-2(1H)-ONE'>3D7</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3Å</td></tr> |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3D7:3-AMINO-5-(1-METHYL-1H-PYRAZOL-4-YL)PYRIDIN-2(1H)-ONE'>3D7</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4cv8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cv8 OCA], [https://pdbe.org/4cv8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4cv8 RCSB], [https://www.ebi.ac.uk/pdbsum/4cv8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4cv8 ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4cv8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cv8 OCA], [https://pdbe.org/4cv8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4cv8 RCSB], [https://www.ebi.ac.uk/pdbsum/4cv8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4cv8 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| - | + | [https://www.uniprot.org/uniprot/TTK_HUMAN TTK_HUMAN] Phosphorylates proteins on serine, threonine, and tyrosine. Probably associated with cell proliferation. Essential for chromosome alignment by enhancing AURKB activity (via direct CDCA8 phosphorylation) at the centromere, and for the mitotic checkpoint.<ref>PMID:18243099</ref> | |
==See Also== | ==See Also== | ||
Current revision
MPS1 kinase with 3-aminopyridin-2-one inhibitors
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