4cyo
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4cyo]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Leishmania_major Leishmania major]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CYO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4CYO FirstGlance]. <br> | <table><tr><td colspan='2'>[[4cyo]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Leishmania_major Leishmania major]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CYO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4CYO FirstGlance]. <br> | ||
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MYA:TETRADECANOYL-COA'>MYA</scene>, <scene name='pdbligand=UEK:N-{5-[(3S,4R)-1-[(3R)-3-AMINO-4-(4-CHLOROPHENYL)BUTANOYL]-4-(HYDROXYMETHYL)PYRROLIDIN-3-YL]-2-CHLOROPHENYL}-2-(4-FLUOROPHENYL)ACETAMIDE'>UEK</scene></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5Å</td></tr> |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MYA:TETRADECANOYL-COA'>MYA</scene>, <scene name='pdbligand=UEK:N-{5-[(3S,4R)-1-[(3R)-3-AMINO-4-(4-CHLOROPHENYL)BUTANOYL]-4-(HYDROXYMETHYL)PYRROLIDIN-3-YL]-2-CHLOROPHENYL}-2-(4-FLUOROPHENYL)ACETAMIDE'>UEK</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4cyo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cyo OCA], [https://pdbe.org/4cyo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4cyo RCSB], [https://www.ebi.ac.uk/pdbsum/4cyo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4cyo ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4cyo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cyo OCA], [https://pdbe.org/4cyo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4cyo RCSB], [https://www.ebi.ac.uk/pdbsum/4cyo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4cyo ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| - | + | [https://www.uniprot.org/uniprot/Q4Q5S8_LEIMA Q4Q5S8_LEIMA] Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins (By similarity). | |
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
Current revision
Leishmania major N-myristoyltransferase in complex with a hybrid inhibitor (compound 21).
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Categories: Large Structures | Leishmania major | Bell AS | Brannigan JA | Goncalves V | Hutton JA | Leatherbarrow RJ | Paape D | Roberts SM | Smith DF | Tate EW | Waugh T | Wilkinson AJ
