8b0a

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Current revision (14:36, 20 September 2023) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 8b0a is ON HOLD until Paper Publication
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==Cryo-EM structure of ALC1 bound to an asymmetric, site-specifically PARylated nucleosome==
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<StructureSection load='8b0a' size='340' side='right'caption='[[8b0a]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8b0a]] is a 11 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens], [https://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8B0A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8B0A FirstGlance]. <br>
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Description:
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8b0a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8b0a OCA], [https://pdbe.org/8b0a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8b0a RCSB], [https://www.ebi.ac.uk/pdbsum/8b0a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8b0a ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CHD1L_HUMAN CHD1L_HUMAN] ATP-dependent chromatin remodeler that mediates chromatin-remodeling following DNA damage (PubMed:19661379, PubMed:29220652, PubMed:29220653, PubMed:33357431, PubMed:34486521, PubMed:34874266, PubMed:34210977). Recruited to DNA damage sites through interaction with poly-ADP-ribose: specifically recognizes and binds histones that are poly-ADP-ribosylated on serine residues in response to DNA damage (PubMed:19661379, PubMed:29220652, PubMed:29220653, PubMed:34874266, PubMed:34486521). Poly-ADP-ribose-binding activates the ATP-dependent chromatin remodeler activity, thereby regulating chromatin during DNA repair (PubMed:19661379, PubMed:29220652, PubMed:29220653, PubMed:34874266, PubMed:34486521). Catalyzes nucleosome sliding away from DNA breaks in an ATP-dependent manner (PubMed:19661379, PubMed:29220652, PubMed:29220653). Chromatin remodeling activity promotes PARP2 removal from chromatin (PubMed:33275888).<ref>PMID:19661379</ref> <ref>PMID:29220652</ref> <ref>PMID:29220653</ref> <ref>PMID:33275888</ref> <ref>PMID:33357431</ref> <ref>PMID:34210977</ref> <ref>PMID:34486521</ref> <ref>PMID:34874266</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Synthetic construct]]
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[[Category: Xenopus laevis]]
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[[Category: Bacic L]]
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[[Category: Deindl S]]
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[[Category: Gaullier G]]

Current revision

Cryo-EM structure of ALC1 bound to an asymmetric, site-specifically PARylated nucleosome

PDB ID 8b0a

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