4ddp

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== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4ddp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DDP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4DDP FirstGlance]. <br>
<table><tr><td colspan='2'>[[4ddp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DDP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4DDP FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ddp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ddp OCA], [https://pdbe.org/4ddp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ddp RCSB], [https://www.ebi.ac.uk/pdbsum/4ddp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ddp ProSAT]</span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.547&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ddp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ddp OCA], [https://pdbe.org/4ddp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ddp RCSB], [https://www.ebi.ac.uk/pdbsum/4ddp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ddp ProSAT]</span></td></tr>
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</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/BECN1_HUMAN BECN1_HUMAN]] Plays a central role in autophagy. Required for the abcission step in cytokinesis. May play a role in antiviral host defense. Protects against infection by a neurovirulent strain of Sindbis virus.<ref>PMID:20208530</ref>
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[https://www.uniprot.org/uniprot/BECN1_HUMAN BECN1_HUMAN] Plays a central role in autophagy. Required for the abcission step in cytokinesis. May play a role in antiviral host defense. Protects against infection by a neurovirulent strain of Sindbis virus.<ref>PMID:20208530</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The Beclin 1 gene is a haplo-insufficient tumor suppressor and plays an essential role in autophagy. However, the molecular mechanism by which Beclin 1 functions remains largely unknown. Here we report the crystal structure of the evolutionarily conserved domain (ECD) of Beclin 1 at 1.6 A resolution. Beclin 1 ECD exhibits a previously unreported fold, with three structural repeats arranged symmetrically around a central axis. Beclin 1 ECD defines a novel class of membrane-binding domain, with a strong preference for lipid membrane enriched with cardiolipin. The tip of a surface loop in Beclin 1 ECD, comprising three aromatic amino acids, acts as a hydrophobic finger to associate with lipid membrane, consequently resulting in the deformation of membrane and liposomes. Mutation of these aromatic residues rendered Beclin 1 unable to stably associate with lipid membrane in vitro and unable to fully rescue autophagy in Beclin 1-knockdown cells in vivo. These observations form an important framework for deciphering the biological functions of Beclin 1.Cell Research advance online publication 7 February 2012; doi:10.1038/cr.2012.24.
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Crystal structure and biochemical analyses reveal Beclin 1 as a novel membrane binding protein.,Huang W, Choi W, Hu W, Mi N, Guo Q, Ma M, Liu M, Tian Y, Lu P, Wang FL, Deng H, Liu L, Gao N, Yu L, Shi Y Cell Res. 2012 Feb 7. doi: 10.1038/cr.2012.24. PMID:22310240<ref>PMID:22310240</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 4ddp" style="background-color:#fffaf0;"></div>
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== References ==
== References ==
<references/>
<references/>

Current revision

crystal structure of Beclin 1 evolutionarily conserved domain(ECD)

PDB ID 4ddp

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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