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8asy
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==SARS-CoV-2 Omicron BA.2.75 RBD in complex with ACE2== | |
| + | <StructureSection load='8asy' size='340' side='right'caption='[[8asy]], [[Resolution|resolution]] 2.85Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[8asy]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8ASY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8ASY FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.85Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8asy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8asy OCA], [https://pdbe.org/8asy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8asy RCSB], [https://www.ebi.ac.uk/pdbsum/8asy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8asy ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/ACE2_HUMAN ACE2_HUMAN] Carboxypeptidase which converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator. Also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. May be an important regulator of heart function. In case of human coronaviruses SARS and HCoV-NL63 infections, serve as functional receptor for the spike glycoprotein of both coronaviruses.<ref>PMID:10969042</ref> <ref>PMID:10924499</ref> <ref>PMID:14647384</ref> | ||
| - | + | ==See Also== | |
| - | + | *[[Spike protein 3D structures|Spike protein 3D structures]] | |
| - | + | == References == | |
| - | [[Category: | + | <references/> |
| - | [[Category: | + | __TOC__ |
| - | [[Category: | + | </StructureSection> |
| - | [[Category: Stuart | + | [[Category: Homo sapiens]] |
| - | [[Category: Zhou | + | [[Category: Large Structures]] |
| + | [[Category: Huo J]] | ||
| + | [[Category: Ren J]] | ||
| + | [[Category: Stuart DI]] | ||
| + | [[Category: Zhou D]] | ||
Current revision
SARS-CoV-2 Omicron BA.2.75 RBD in complex with ACE2
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Categories: Homo sapiens | Large Structures | Huo J | Ren J | Stuart DI | Zhou D
