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8ejl
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Structure of HIV-1 capsid declination in complex with CPSF6-FG peptide== | |
| - | + | <StructureSection load='8ejl' size='340' side='right'caption='[[8ejl]], [[Resolution|resolution]] 3.90Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8ejl]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8EJL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8EJL FirstGlance]. <br> | |
| - | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8ejl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8ejl OCA], [https://pdbe.org/8ejl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8ejl RCSB], [https://www.ebi.ac.uk/pdbsum/8ejl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8ejl ProSAT]</span></td></tr> | |
| - | [[Category: | + | </table> |
| - | [[Category: | + | == Function == |
| - | [[Category: | + | [https://www.uniprot.org/uniprot/GAG_HV1N5 GAG_HV1N5] Matrix protein p17 targets Gag and Gag-Pol polyproteins to the plasma membrane via a multipartite membrane binding signal, that includes its myristoylated N-terminus. Also mediates nuclear localization of the preintegration complex. Implicated in the release from host cell mediated by Vpu. Capsid protein p24 forms the conical core of the virus that encapsulates the genomic RNA-nucleocapsid complex. Nucleocapsid protein p7 encapsulates and protects viral dimeric unspliced (genomic) RNA. Binds these RNAs through its zinc fingers. p6-gag plays a role in budding of the assembled particle by interacting with the host class E VPS proteins TSG101 and PDCD6IP/AIP1 (By similarity). |
| - | [[Category: Ganser-Pornillos | + | __TOC__ |
| - | [[Category: Dos Santos | + | </StructureSection> |
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Human immunodeficiency virus 1]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Ganser-Pornillos BK]] | ||
| + | [[Category: Pornillos O]] | ||
| + | [[Category: Schirra RT]] | ||
| + | [[Category: Dos Santos NFB]] | ||
Current revision
Structure of HIV-1 capsid declination in complex with CPSF6-FG peptide
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