1iiz

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[[Image:1iiz.gif|left|200px]]
 
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==Crystal Structure of the Induced Antibacterial Protein from Tasar Silkworm, Antheraea mylitta==
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The line below this paragraph, containing "STRUCTURE_1iiz", creates the "Structure Box" on the page.
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<StructureSection load='1iiz' size='340' side='right'caption='[[1iiz]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1iiz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Antheraea_mylitta Antheraea mylitta]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IIZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1IIZ FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1iiz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1iiz OCA], [https://pdbe.org/1iiz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1iiz RCSB], [https://www.ebi.ac.uk/pdbsum/1iiz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1iiz ProSAT]</span></td></tr>
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{{STRUCTURE_1iiz| PDB=1iiz | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/LYS_ANTMY LYS_ANTMY]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ii/1iiz_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1iiz ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The crystal structure of an antibacterial protein of immune origin (TSWAB), purified from tasar silkworm (Antheraea mylitta) larvae after induction by Escherichia coli infection, has been determined. This is the first insect lysozyme structure and represents induced lysozymes of innate immunity. The core structure of TSWAB is similar to c-type lysozymes and alpha-lactalbumins. However, TSWAB shows significant differences with respect to the other two proteins in the exposed loop regions. The catalytic residues in TSWAB are conserved with respect to the chicken lysozyme, indicating a common mechanism of action. However, differences in the noncatalytic residues in the substrate binding groove imply subtle differences in the specificity and the level of activity. Thus, conformational differences between TSWAB and chicken lysozyme exist, whereas functional mechanisms appear to be similar. On the other hand, alpha-lactalbumins and c-type lysozymes exhibit drastically different functions with conserved molecular conformation. It is evident that a common molecular scaffold is exploited in the three enzymes for apparently different physiological roles. It can be inferred on the basis of the structure-function comparison of these three proteins having common phylogenetic origin that the conformational changes in a protein are minimal during rapid evolution as compared with those in the normal course of evolution.
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'''Crystal Structure of the Induced Antibacterial Protein from Tasar Silkworm, Antheraea mylitta'''
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Structure of the induced antibacterial protein from tasar silkworm, Antheraea mylitta. Implications to molecular evolution.,Jain D, Nair DT, Swaminathan GJ, Abraham EG, Nagaraju J, Salunke DM J Biol Chem. 2001 Nov 2;276(44):41377-82. Epub 2001 Aug 24. PMID:11522783<ref>PMID:11522783</ref>
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==Overview==
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The crystal structure of an antibacterial protein of immune origin (TSWAB), purified from tasar silkworm (Antheraea mylitta) larvae after induction by Escherichia coli infection, has been determined. This is the first insect lysozyme structure and represents induced lysozymes of innate immunity. The core structure of TSWAB is similar to c-type lysozymes and alpha-lactalbumins. However, TSWAB shows significant differences with respect to the other two proteins in the exposed loop regions. The catalytic residues in TSWAB are conserved with respect to the chicken lysozyme, indicating a common mechanism of action. However, differences in the noncatalytic residues in the substrate binding groove imply subtle differences in the specificity and the level of activity. Thus, conformational differences between TSWAB and chicken lysozyme exist, whereas functional mechanisms appear to be similar. On the other hand, alpha-lactalbumins and c-type lysozymes exhibit drastically different functions with conserved molecular conformation. It is evident that a common molecular scaffold is exploited in the three enzymes for apparently different physiological roles. It can be inferred on the basis of the structure-function comparison of these three proteins having common phylogenetic origin that the conformational changes in a protein are minimal during rapid evolution as compared with those in the normal course of evolution.
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==About this Structure==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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1IIZ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Antheraea_mylitta Antheraea mylitta]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IIZ OCA].
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</div>
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<div class="pdbe-citations 1iiz" style="background-color:#fffaf0;"></div>
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==Reference==
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==See Also==
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Structure of the induced antibacterial protein from tasar silkworm, Antheraea mylitta. Implications to molecular evolution., Jain D, Nair DT, Swaminathan GJ, Abraham EG, Nagaraju J, Salunke DM, J Biol Chem. 2001 Nov 2;276(44):41377-82. Epub 2001 Aug 24. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11522783 11522783]
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*[[Lysozyme 3D structures|Lysozyme 3D structures]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Antheraea mylitta]]
[[Category: Antheraea mylitta]]
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[[Category: Lysozyme]]
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[[Category: Large Structures]]
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[[Category: Single protein]]
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[[Category: Abraham EG]]
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[[Category: Abraham, E G.]]
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[[Category: Jain D]]
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[[Category: Jain, D.]]
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[[Category: Nagaraju J]]
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[[Category: Nagaraju, J.]]
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[[Category: Nair DT]]
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[[Category: Nair, D T.]]
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[[Category: Salunke DM]]
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[[Category: Salunke, D M.]]
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[[Category: Swaminathan GJ]]
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[[Category: Swaminathan, G J.]]
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[[Category: Hydrolase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 20:03:17 2008''
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Current revision

Crystal Structure of the Induced Antibacterial Protein from Tasar Silkworm, Antheraea mylitta

PDB ID 1iiz

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