Mevalonate pathway
From Proteopedia
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| - | + | <StructureSection load='4c2j' size='350' side='right' caption='Human 3-ketoacyl-CoA complex with CoA and ethylene glycol (PDB code [[4c2j]])' scene='44/447919/Cv/7'> | |
| + | Production of mevalonate is the rate-limiting and irreversible step in cholesterol synthesis and is the site of action for statins. | ||
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| + | Acetyl-CoA is coming from [[Citric Acid Cycle]]. | ||
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| + | '''Mevalonate pathway''' | ||
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| + | ''Acetoacetyl-CoA thiolase'' | ||
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| + | *[[Acetoacetyl-CoA thiolase]] | ||
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| + | ''Hydroxymethylglutaryl-CoA synthase or HMG-CoA synthase; EC 2.3.3.10'' | ||
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| + | *[[1xpk]] | ||
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| + | ''HMG-CoA Reductase'' | ||
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| + | *[[HMG-CoA Reductase]] | ||
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| + | ''Mevalonate kinase'' | ||
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| + | *[[Mevalonate kinase]] | ||
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| + | ''Phosphomevalonate kinase'' | ||
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| + | *The Crystal Structure of Human Phosphomavelonate Kinase At 1.8 A Resolution [[3ch4]] | ||
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| + | ''Mevalonate-5-pyrophosphate decarboxylase'' | ||
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| + | Diphosphomevalonate decarboxylase (EC 4.1.1.33), most commonly referred to in scientific literature as mevalonate diphosphate decarboxylase. | ||
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| + | *[[Sandbox Reserved 333|Mevalonate Diphosphate Decarboxylase]] | ||
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| + | ''Isopentenyl pyrophosphate isomerase'' | ||
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| + | Isopentenyl pyrophosphate isomerase (EC 5.3.3.2, IPP isomerase), also known as Isopentenyl-diphosphate delta isomerase | ||
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| + | *[[Isopentenyl-diphosphate delta-isomerase]] | ||
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| + | Mevalonate is finally converted to isopentenyl pyrophosphate. | ||
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| + | </StructureSection> | ||
| + | == References == | ||
| + | <references/> | ||
Current revision
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