Mevalonate pathway

(Difference between revisions)

Revision as of 11:06, 3 October 2022 (edit) Alexander Berchansky (Talk \| contribs) ← Previous diff		Current revision (11:07, 3 October 2022) (edit) (undo) Alexander Berchansky (Talk \| contribs)
Line 1:		Line 1:
-	<StructureSection load='' size='350' side='right~~' scene='HMG-CoA_Reductase/1dq8_starting_scene/1~~' caption='~~Crystal Structure of HMG~~-CoA, (PDB code [[~~1dq8~~]])'>	+	<StructureSection load='4c2j' size='350' side='right' caption='Human 3-ketoacyl-CoA complex with CoA and ethylene glycol (PDB code [[4c2j]])' scene='44/447919/Cv/7'>
	Production of mevalonate is the rate-limiting and irreversible step in cholesterol synthesis and is the site of action for statins.		Production of mevalonate is the rate-limiting and irreversible step in cholesterol synthesis and is the site of action for statins.

Current revision

spinqualitylabelsall models

Human 3-ketoacyl-CoA complex with CoA and ethylene glycol (PDB code 4c2j)

Show:Asymmetric Unit Biological Assembly

Drag the structure with the mouse to rotate

Production of mevalonate is the rate-limiting and irreversible step in cholesterol synthesis and is the site of action for statins.

Acetyl-CoA is coming from Citric Acid Cycle.

Mevalonate pathway

Acetoacetyl-CoA thiolase

Hydroxymethylglutaryl-CoA synthase or HMG-CoA synthase; EC 2.3.3.10

HMG-CoA Reductase

Mevalonate kinase

Phosphomevalonate kinase

The Crystal Structure of Human Phosphomavelonate Kinase At 1.8 A Resolution 3ch4

Mevalonate-5-pyrophosphate decarboxylase

Diphosphomevalonate decarboxylase (EC 4.1.1.33), most commonly referred to in scientific literature as mevalonate diphosphate decarboxylase.

Isopentenyl pyrophosphate isomerase

Isopentenyl pyrophosphate isomerase (EC 5.3.3.2, IPP isomerase), also known as Isopentenyl-diphosphate delta isomerase

Mevalonate is finally converted to isopentenyl pyrophosphate.