4f40
From Proteopedia
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4f40]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Leishmania_major Leishmania major]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4F40 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4F40 FirstGlance]. <br> | <table><tr><td colspan='2'>[[4f40]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Leishmania_major Leishmania major]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4F40 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4F40 FirstGlance]. <br> | ||
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6Å</td></tr> |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4f40 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4f40 OCA], [https://pdbe.org/4f40 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4f40 RCSB], [https://www.ebi.ac.uk/pdbsum/4f40 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4f40 ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4f40 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4f40 OCA], [https://pdbe.org/4f40 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4f40 RCSB], [https://www.ebi.ac.uk/pdbsum/4f40 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4f40 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/PGFS_LEIMA PGFS_LEIMA] Catalyzes the NADP-dependent formation of prostaglandin F2-alpha from prostaglandin H2. Has also aldo/ketoreductase activity toward the synthetic substrates 9,10-phenanthrenequinone and p-nitrobenzaldehyde.<ref>PMID:12633659</ref> | [https://www.uniprot.org/uniprot/PGFS_LEIMA PGFS_LEIMA] Catalyzes the NADP-dependent formation of prostaglandin F2-alpha from prostaglandin H2. Has also aldo/ketoreductase activity toward the synthetic substrates 9,10-phenanthrenequinone and p-nitrobenzaldehyde.<ref>PMID:12633659</ref> | ||
| - | <div style="background-color:#fffaf0;"> | ||
| - | == Publication Abstract from PubMed == | ||
| - | The crystal structures of prostaglandin F synthase (PGF) from both Leishmania major and Trypanosoma cruzi with and without their cofactor NADP have been determined to resolutions of 2.6 A for T. cruzi PGF, 1.25 A for T. cruzi PGF with NADP, 1.6 A for L. major PGF and 1.8 A for L. major PGF with NADP. These structures were determined by molecular replacement to a final R factor of less than 18.6% (Rfree of less than 22.9%). PGF in the infectious protozoa L. major and T. cruzi is a potential therapeutic target. | ||
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| - | Structures of prostaglandin F synthase from the protozoa Leishmania major and Trypanosoma cruzi with NADP.,Moen SO, Fairman JW, Barnes SR, Sullivan A, Nakazawa-Hewitt S, Van Voorhis WC, Staker BL, Lorimer DD, Myler PJ, Edwards TE Acta Crystallogr F Struct Biol Commun. 2015 May;71(Pt 5):609-14. doi:, 10.1107/S2053230X15006883. Epub 2015 Apr 21. PMID:25945716<ref>PMID:25945716</ref> | ||
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| - | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| - | </div> | ||
| - | <div class="pdbe-citations 4f40" style="background-color:#fffaf0;"></div> | ||
==See Also== | ==See Also== | ||
| - | *[[Prostaglandin F synthase|Prostaglandin F synthase]] | + | *[[Prostaglandin F synthase 3D structures|Prostaglandin F synthase 3D structures]] |
== References == | == References == | ||
<references/> | <references/> | ||
Current revision
X-ray crystal structure of Apo prostaglandin f synthase from Leishmania major Friedlin
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