8b4l
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of a selenomethionine-labeled hydropyrene synthase (M75L variant) in its closed conformation== | |
| - | + | <StructureSection load='8b4l' size='340' side='right'caption='[[8b4l]], [[Resolution|resolution]] 3.39Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8b4l]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_clavuligerus Streptomyces clavuligerus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8B4L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8B4L FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.394Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AHD:4-AMINO-1-HYDROXYBUTANE-1,1-DIYLDIPHOSPHONATE'>AHD</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8b4l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8b4l OCA], [https://pdbe.org/8b4l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8b4l RCSB], [https://www.ebi.ac.uk/pdbsum/8b4l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8b4l ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/HPS_STRCL HPS_STRCL] Terpene synthase that catalyzes the conversion of geranylgeranyl diphosphate (GGPP) into a mixture of diterpenes, including hydropyrene (HP), hydropyrenol (HPol), isoelisabethatriene and traces of isoelisabethatriene B (PubMed:25605043, PubMed:28696553, PubMed:35965858). Hydropyrene is the main product (PubMed:25605043, PubMed:28696553). Some other diterpenoids are also produced in very low quantities (PubMed:25605043).<ref>PMID:25605043</ref> <ref>PMID:28696553</ref> <ref>PMID:35965858</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Streptomyces clavuligerus]] | ||
| + | [[Category: Driller R]] | ||
| + | [[Category: Helmer CPO]] | ||
| + | [[Category: Loll B]] | ||
Current revision
Crystal structure of a selenomethionine-labeled hydropyrene synthase (M75L variant) in its closed conformation
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