8eqt
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 8eqt is ON HOLD Authors: Miller, A.N., Houlihan, P.R., Matamala, E., Cabezas-Bratesco, D., Lee, G.Y., Cristofori-Armstrong, B., Dilan, T.L., Sanchez...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Structure of SARS-CoV-2 Orf3a in plasma membrane-like environment, MSP1D1 nanodisc== | |
| - | + | <StructureSection load='8eqt' size='340' side='right'caption='[[8eqt]], [[Resolution|resolution]] 3.40Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8eqt]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Severe_acute_respiratory_syndrome_coronavirus_2 Severe acute respiratory syndrome coronavirus 2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8EQT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8EQT FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.4Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PEE:1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE'>PEE</scene></td></tr> |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8eqt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8eqt OCA], [https://pdbe.org/8eqt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8eqt RCSB], [https://www.ebi.ac.uk/pdbsum/8eqt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8eqt ProSAT]</span></td></tr> |
| - | [[Category: | + | </table> |
| - | [[Category: | + | == Function == |
| - | [[Category: | + | [https://www.uniprot.org/uniprot/AP3A_SARS2 AP3A_SARS2] Forms homotetrameric potassium sensitive ion channels (viroporin) and may modulate virus release. Up-regulates expression of fibrinogen subunits FGA, FGB and FGG in host lung epithelial cells. Induces apoptosis in cell culture. Downregulates the type 1 interferon receptor by inducing serine phosphorylation within the IFN alpha-receptor subunit 1 (IFNAR1) degradation motif and increasing IFNAR1 ubiquitination.[UniProtKB:P59632] |
| - | [[Category: | + | __TOC__ |
| - | [[Category: | + | </StructureSection> |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: Lee | + | [[Category: Severe acute respiratory syndrome coronavirus 2]] |
| - | [[Category: Matthies | + | [[Category: Brauchi SE]] |
| - | [[Category: | + | [[Category: Cabezas-Bratesco D]] |
| - | [[Category: | + | [[Category: Clapham DE]] |
| - | [[Category: | + | [[Category: Cristofori-Armstrong B]] |
| - | [[Category: Yan | + | [[Category: Dilan TL]] |
| - | [[Category: | + | [[Category: Houlihan PR]] |
| + | [[Category: Lee GY]] | ||
| + | [[Category: Matamala E]] | ||
| + | [[Category: Matthies D]] | ||
| + | [[Category: Miller AN]] | ||
| + | [[Category: Ren D]] | ||
| + | [[Category: Sanchez-Martinez S]] | ||
| + | [[Category: Yan R]] | ||
| + | [[Category: Yu Z]] | ||
Current revision
Structure of SARS-CoV-2 Orf3a in plasma membrane-like environment, MSP1D1 nanodisc
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