7fre

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'''Unreleased structure'''
 
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The entry 7fre is ON HOLD
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==PanDDA analysis group deposition -- Crystal structure of PTP1B after initial refinement with no ligand modeled==
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<StructureSection load='7fre' size='340' side='right'caption='[[7fre]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[7fre]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7FRE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7FRE FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.85&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7fre FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7fre OCA], [https://pdbe.org/7fre PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7fre RCSB], [https://www.ebi.ac.uk/pdbsum/7fre PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7fre ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PTN1_HUMAN PTN1_HUMAN] Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion.<ref>PMID:21135139</ref> <ref>PMID:22169477</ref>
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Authors: Mehlman, T., Biel, J., Azeem, S.M., Nelson, E.R., Hossain, S., Dunnett, L.E., Paterson, N.G., Douangamath, A., Talon, R., Axford, D., Orins, H., von Delft, F., Keedy, D.A.
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==See Also==
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*[[Tyrosine phosphatase 3D structures|Tyrosine phosphatase 3D structures]]
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Description: PanDDA analysis group deposition --Crystal structure of PTP1B after initial refinement with no ligand modeled
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== References ==
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[[Category: Unreleased Structures]]
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<references/>
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[[Category: Mehlman, T]]
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__TOC__
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[[Category: Biel, J]]
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</StructureSection>
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[[Category: Nelson, E.R]]
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[[Category: Homo sapiens]]
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[[Category: Azeem, S.M]]
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[[Category: Large Structures]]
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[[Category: Paterson, N.G]]
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[[Category: Axford D]]
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[[Category: Dunnett, L.E]]
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[[Category: Azeem SM]]
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[[Category: Talon, R]]
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[[Category: Biel J]]
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[[Category: Keedy, D.A]]
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[[Category: Douangamath A]]
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[[Category: Douangamath, A]]
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[[Category: Dunnett LE]]
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[[Category: Hossain, S]]
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[[Category: Hossain S]]
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[[Category: Orins, H]]
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[[Category: Keedy DA]]
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[[Category: Von Delft, F]]
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[[Category: Mehlman T]]
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[[Category: Axford, D]]
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[[Category: Nelson ER]]
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[[Category: Orins H]]
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[[Category: Paterson NG]]
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[[Category: Talon R]]
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[[Category: Von Delft F]]

Current revision

PanDDA analysis group deposition -- Crystal structure of PTP1B after initial refinement with no ligand modeled

PDB ID 7fre

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