8gyd
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Structure of Schistosoma japonicum Glutathione S-transferase bound with the ligand complex of 16== | |
| - | + | <StructureSection load='8gyd' size='340' side='right'caption='[[8gyd]], [[Resolution|resolution]] 1.70Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8gyd]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Schistosoma_japonicum Schistosoma japonicum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8GYD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8GYD FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0IH:(2R)-2-[[2-(5-chloranylthiophen-2-yl)-4-oxidanylidene-6-[2-(1H-1,2,3,4-tetrazol-5-yl)phenyl]quinazolin-3-yl]methyl]-3-(4-chlorophenyl)propanoic+acid'>0IH</scene>, <scene name='pdbligand=EOH:ETHANOL'>EOH</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8gyd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8gyd OCA], [https://pdbe.org/8gyd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8gyd RCSB], [https://www.ebi.ac.uk/pdbsum/8gyd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8gyd ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/GST26_SCHJA GST26_SCHJA] Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. GST isoenzymes appear to play a central role in the parasite detoxification system. Other functions are also suspected including a role in increasing the solubility of haematin in the parasite gut. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Schistosoma japonicum]] | ||
| + | [[Category: Hu H]] | ||
| + | [[Category: Jin R]] | ||
| + | [[Category: Lu X]] | ||
| + | [[Category: Song W]] | ||
| + | [[Category: Wen X]] | ||
| + | [[Category: Zhu J]] | ||
Current revision
Structure of Schistosoma japonicum Glutathione S-transferase bound with the ligand complex of 16
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Categories: Large Structures | Schistosoma japonicum | Hu H | Jin R | Lu X | Song W | Wen X | Zhu J
