8ew4

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(New page: '''Unreleased structure''' The entry 8ew4 is ON HOLD Authors: Gucwa, M., Cooper, D.R., Unciano, J., Lea, K., Kim, L., Lenkiewicz, J., Starban, I., Stewart, A.J., Minor, W., Center for S...)
Current revision (10:24, 25 October 2023) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 8ew4 is ON HOLD
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==Human Serum Albumin with Cobalt (II) and Myristic Acid - crystal 1==
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<StructureSection load='8ew4' size='340' side='right'caption='[[8ew4]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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Authors: Gucwa, M., Cooper, D.R., Unciano, J., Lea, K., Kim, L., Lenkiewicz, J., Starban, I., Stewart, A.J., Minor, W., Center for Structural Genomics of Infectious Diseases (CSGID)
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8ew4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8EW4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8EW4 FirstGlance]. <br>
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Description: Human Serum Albumin with Cobalt (II) and Myristic Acid -crystal 1
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene>, <scene name='pdbligand=MYR:MYRISTIC+ACID'>MYR</scene></td></tr>
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[[Category: Lenkiewicz, J]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8ew4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8ew4 OCA], [https://pdbe.org/8ew4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8ew4 RCSB], [https://www.ebi.ac.uk/pdbsum/8ew4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8ew4 ProSAT]</span></td></tr>
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[[Category: Starban, I]]
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</table>
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[[Category: Center For Structural Genomics Of Infectious Diseases (Csgid)]]
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== Disease ==
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[[Category: Stewart, A.J]]
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[https://www.uniprot.org/uniprot/ALBU_HUMAN ALBU_HUMAN] Defects in ALB are a cause of familial dysalbuminemic hyperthyroxinemia (FDH) [MIM:[https://omim.org/entry/103600 103600]. FDH is a form of euthyroid hyperthyroxinemia that is due to increased affinity of ALB for T(4). It is the most common cause of inherited euthyroid hyperthyroxinemia in Caucasian population.<ref>PMID:8048949</ref> <ref>PMID:7852505</ref> <ref>PMID:9329347</ref> <ref>PMID:9589637</ref>
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[[Category: Lea, K]]
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== Function ==
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[[Category: Kim, L]]
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[https://www.uniprot.org/uniprot/ALBU_HUMAN ALBU_HUMAN] Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc.<ref>PMID:19021548</ref>
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[[Category: Cooper, D.R]]
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== References ==
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[[Category: Gucwa, M]]
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<references/>
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[[Category: Minor, W]]
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__TOC__
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[[Category: Unciano, J]]
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Cooper DR]]
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[[Category: Gucwa M]]
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[[Category: Kim L]]
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[[Category: Lea K]]
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[[Category: Lenkiewicz J]]
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[[Category: Minor W]]
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[[Category: Starban I]]
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[[Category: Stewart AJ]]
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[[Category: Unciano J]]

Current revision

Human Serum Albumin with Cobalt (II) and Myristic Acid - crystal 1

PDB ID 8ew4

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