4hvz

</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hvz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hvz OCA], [https://pdbe.org/4hvz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hvz RCSB], [https://www.ebi.ac.uk/pdbsum/4hvz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hvz ProSAT]</span></td></tr>

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== Publication Abstract from PubMed ==

An outer membrane protein BP26/OMP28 of Brucella, BP26, is identified as a major immunodominant antigen and widely used as a diagnostic marker and for vaccination against Brucellosis. BP26 belongs to the family of proteins that contains a SIMPL (signaling molecule that associates with the mouse pelle-like kinase) domain, whose structure and function have been unknown. Here, we present the crystal structure of BP26 revealing that 16 BP26 molecules form a novel channel-like assembly as also shown by electron microscopy analysis. Eight BP26 molecules forming a ring structure contain a hole at the center of the octamer, and another octamer interacts with each other to form a channel having a large internal cavity. BP26 is found to be structurally similar to a bacteriophage protein involved in infection, implicating that BP26 might function during Brucella infection. In addition, the BP26 structure suggests that the protein functions as a multimeric channel-like form and provides a canonical model for the SIMPL domains.

Brucella Immunogenic BP26 Forms a Channel-like Structure.,Kim D, Park J, Kim SJ, Soh YM, Kim HM, Oh BH, Song JJ J Mol Biol. 2013 Jan 23. pii: S0022-2836(13)00031-4. doi:, 10.1016/j.jmb.2013.01.015. PMID:23353825<ref>PMID:23353825</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>

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== References ==

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