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8ewv

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Current revision (12:32, 4 October 2023) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 8ewv is ON HOLD until Paper Publication
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==DNA-encoded library (DEL)-enabled discovery of proximity inducing small molecules==
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<StructureSection load='8ewv' size='340' side='right'caption='[[8ewv]], [[Resolution|resolution]] 3.40&Aring;' scene=''>
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Authors: Schreiber, S.L., Shu, W., Ma, X., Michaud, G., Bonazzi, S., Berst, F.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8ewv]] is a 24 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8EWV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8EWV FirstGlance]. <br>
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Description: DNA-encoded library (DEL)-enabled discovery of proximity inducing small molecules
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.4&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=X5K:N-{3-[1-(4-{[3-(cyclopropylamino)-3-oxopropyl](methyl)amino}-6-{methyl[(1,3,5-trimethyl-1H-pyrazol-4-yl)methyl]amino}-1,3,5-triazin-2-yl)piperidin-4-yl]propanoyl}-3-methyl-L-valyl-(4R)-4-hydroxy-N-{[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}-L-prolinamide'>X5K</scene></td></tr>
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[[Category: Bonazzi, S]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8ewv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8ewv OCA], [https://pdbe.org/8ewv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8ewv RCSB], [https://www.ebi.ac.uk/pdbsum/8ewv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8ewv ProSAT]</span></td></tr>
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[[Category: Shu, W]]
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</table>
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[[Category: Schreiber, S.L]]
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== Function ==
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[[Category: Berst, F]]
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[https://www.uniprot.org/uniprot/ELOB_HUMAN ELOB_HUMAN] SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex).<ref>PMID:7638163</ref> <ref>PMID:15590694</ref> The elongin BC complex seems to be involved as an adapter protein in the proteasomal degradation of target proteins via different E3 ubiquitin ligase complexes, including the von Hippel-Lindau ubiquitination complex CBC(VHL). By binding to BC-box motifs it seems to link target recruitment subunits, like VHL and members of the SOCS box family, to Cullin/RBX1 modules that activate E2 ubiquitination enzymes.<ref>PMID:7638163</ref> <ref>PMID:15590694</ref>
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[[Category: Michaud, G]]
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== References ==
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[[Category: Ma, X]]
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Berst F]]
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[[Category: Bonazzi S]]
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[[Category: Ma X]]
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[[Category: Michaud G]]
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[[Category: Schreiber SL]]
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[[Category: Shu W]]

Current revision

DNA-encoded library (DEL)-enabled discovery of proximity inducing small molecules

PDB ID 8ewv

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