1j1j

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (23:40, 27 December 2023) (edit) (undo)
 
(10 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1j1j.gif|left|200px]]
 
-
<!--
+
==Crystal Structure of human Translin==
-
The line below this paragraph, containing "STRUCTURE_1j1j", creates the "Structure Box" on the page.
+
<StructureSection load='1j1j' size='340' side='right'caption='[[1j1j]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[1j1j]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1J1J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1J1J FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
-
-->
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1j1j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1j1j OCA], [https://pdbe.org/1j1j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1j1j RCSB], [https://www.ebi.ac.uk/pdbsum/1j1j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1j1j ProSAT]</span></td></tr>
-
{{STRUCTURE_1j1j| PDB=1j1j | SCENE= }}
+
</table>
-
 
+
== Function ==
-
'''Crystal Structure of human Translin'''
+
[https://www.uniprot.org/uniprot/TSN_HUMAN TSN_HUMAN] DNA-binding protein that specifically recognizes consensus sequences at the breakpoint junctions in chromosomal translocations, mostly involving immunoglobulin (Ig)/T-cell receptor gene segments. Seems to recognize single-stranded DNA ends generated by staggered breaks occurring at recombination hot spots.<ref>PMID:9111049</ref> <ref>PMID:21552258</ref> Exhibits both single-stranded and double-stranded endoribonuclease activity. May act as an activator of RNA-induced silencing complex (RISC) by facilitating endonucleolytic cleavage of the siRNA passenger strand.<ref>PMID:9111049</ref> <ref>PMID:21552258</ref>
-
 
+
== Evolutionary Conservation ==
-
 
+
[[Image:Consurf_key_small.gif|200px|right]]
-
==Overview==
+
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/j1/1j1j_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1j1j ConSurf].
 +
<div style="clear:both"></div>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
The structure of human translin at 2.2 A resolution is reported in space group C222(1). Translin forms a tetramer in the asymmetric unit. Although the monomer structure is almost the same as the crystal structure of murine translin in space group P2(1)2(1)2, the relative positions of the tetramers differ between the human and murine translins. This suggests that the multimerization of translin is flexible; the flexibility may be related to the binding to DNA/RNA.
The structure of human translin at 2.2 A resolution is reported in space group C222(1). Translin forms a tetramer in the asymmetric unit. Although the monomer structure is almost the same as the crystal structure of murine translin in space group P2(1)2(1)2, the relative positions of the tetramers differ between the human and murine translins. This suggests that the multimerization of translin is flexible; the flexibility may be related to the binding to DNA/RNA.
-
==About this Structure==
+
Structure of human translin at 2.2 A resolution.,Sugiura I, Sasaki C, Hasegawa T, Kohno T, Sugio S, Moriyama H, Kasai M, Matsuzaki T Acta Crystallogr D Biol Crystallogr. 2004 Apr;60(Pt 4):674-9. Epub 2004, Mar 23. PMID:15039555<ref>PMID:15039555</ref>
-
1J1J is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1J1J OCA].
+
-
==Reference==
+
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-
Structure of human translin at 2.2 A resolution., Sugiura I, Sasaki C, Hasegawa T, Kohno T, Sugio S, Moriyama H, Kasai M, Matsuzaki T, Acta Crystallogr D Biol Crystallogr. 2004 Apr;60(Pt 4):674-9. Epub 2004, Mar 23. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15039555 15039555]
+
</div>
 +
<div class="pdbe-citations 1j1j" style="background-color:#fffaf0;"></div>
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Single protein]]
+
[[Category: Large Structures]]
-
[[Category: Hasegawa, T.]]
+
[[Category: Hasegawa T]]
-
[[Category: Kasai, M.]]
+
[[Category: Kasai M]]
-
[[Category: Kohno, T.]]
+
[[Category: Kohno T]]
-
[[Category: Matsuzaki, T.]]
+
[[Category: Matsuzaki T]]
-
[[Category: Moriyama, H.]]
+
[[Category: Moriyama H]]
-
[[Category: Sasaki, C.]]
+
[[Category: Sasaki C]]
-
[[Category: Sugio, S.]]
+
[[Category: Sugio S]]
-
[[Category: Sugiura, I.]]
+
[[Category: Sugiura I]]
-
[[Category: Rna binding protein]]
+
-
[[Category: Ssdna binding protein]]
+
-
[[Category: Testis/brain rna binding protein]]
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 20:41:17 2008''
+

Current revision

Crystal Structure of human Translin

PDB ID 1j1j

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1j1j"
Personal tools