Coronavirus Disease 2019 (COVID-19)

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (19:08, 10 December 2023) (edit) (undo)
 
(2 intermediate revisions not shown.)
Line 3: Line 3:
[[Image:Ezgif.com-video-to-gif 240px 65pc speed.gif|left|240px|thumb|<span style="font-size:100%">SARS-CoV-2 virus. The <span style="color:blue">spikes</span>, that adorn the <span style="color:red">'''virus surface'''</span>, impart a '''''corona''''' like appearance [http://www.drugtargetreview.com/news/57287/3d-visualisation-of-covid-19-surface-released-for-researchers (Fusion Animation)].</span>]]
[[Image:Ezgif.com-video-to-gif 240px 65pc speed.gif|left|240px|thumb|<span style="font-size:100%">SARS-CoV-2 virus. The <span style="color:blue">spikes</span>, that adorn the <span style="color:red">'''virus surface'''</span>, impart a '''''corona''''' like appearance [http://www.drugtargetreview.com/news/57287/3d-visualisation-of-covid-19-surface-released-for-researchers (Fusion Animation)].</span>]]
<span style="font-size:100%">
<span style="font-size:100%">
-
A novel coronavirus SARS-CoV-2, detected in Wuhan, China in 2019, was found to cause severe respiratory illness named '''''COVID-19'''''<ref>[http://www.who.int/emergencies/diseases/novel-coronavirus-2019/technical-guidance/naming-the-coronavirus-disease-(covid-2019)-and-the-virus-that-causes-it Naming the coronavirus disease (COVID-19) and the virus that causes it]</ref>.
+
A novel coronavirus SARS-CoV-2, detected in Wuhan, China in 2019, was found to cause severe respiratory illness named '''''COVID-19'''''<ref>[http://www.who.int/emergencies/diseases/novel-coronavirus-2019/technical-guidance/naming-the-coronavirus-disease-(covid-2019)-and-the-virus-that-causes-it Naming the coronavirus disease (COVID-19) and the virus that causes it]</ref> ('''CO'''rona '''VI'''rus '''D'''isease-20'''19''').
There’s a new [http://go.usa.gov/xw9MV NCBI site] on COVID-19/SARS-CoV-2. It will help bench scientists, bioinformaticians, clinicians & others connect with information they need to study SARS-CoV-2 and end the pandemic.
There’s a new [http://go.usa.gov/xw9MV NCBI site] on COVID-19/SARS-CoV-2. It will help bench scientists, bioinformaticians, clinicians & others connect with information they need to study SARS-CoV-2 and end the pandemic.
Line 9: Line 9:
A video (by [http://elarasystems.com Elara)] shows how the virus [http://youtu.be/hwVl_-lnoys '''interacts with its human (host) cells'''], via its ''spike'' proteins<ref name="Pillay">PMID:32376714</ref><ref name="McLellan">PMID:32075877</ref><ref name="Veesler">PMID:32155444</ref><ref name="wrobel">PMID: 32647346</ref><ref name="thomas">PMID:12360192</ref><ref name="wang-qi">PMID:32275855</ref>, thus permitting the viral genome to enter its host & begin infection. The spike protein is induced for optimal binding when it is clipped by a protease (see animation on right side) and more details at '''[[SARS-CoV-2_protein_S_activation_by_furin]]'''. Subsequently, it undergoes a dramatic transformation to induce membrane fusion and infection, explained with a morph animation at '''[[SARS-CoV-2 spike protein fusion transformation]]'''.
A video (by [http://elarasystems.com Elara)] shows how the virus [http://youtu.be/hwVl_-lnoys '''interacts with its human (host) cells'''], via its ''spike'' proteins<ref name="Pillay">PMID:32376714</ref><ref name="McLellan">PMID:32075877</ref><ref name="Veesler">PMID:32155444</ref><ref name="wrobel">PMID: 32647346</ref><ref name="thomas">PMID:12360192</ref><ref name="wang-qi">PMID:32275855</ref>, thus permitting the viral genome to enter its host & begin infection. The spike protein is induced for optimal binding when it is clipped by a protease (see animation on right side) and more details at '''[[SARS-CoV-2_protein_S_activation_by_furin]]'''. Subsequently, it undergoes a dramatic transformation to induce membrane fusion and infection, explained with a morph animation at '''[[SARS-CoV-2 spike protein fusion transformation]]'''.
</span>
</span>
- 
- 
Line 19: Line 17:
default [https://ourworldindata.org/grapher/biweekly-growth-covid-cases Our World site with the most recent data]
default [https://ourworldindata.org/grapher/biweekly-growth-covid-cases Our World site with the most recent data]
</imagemap>
</imagemap>
-
Clicking the above image goes to the [https://ourworldindata.org/grapher/biweekly-growth-covid-cases Our World in Data] site with the most recent data]
+
Clicking the above image goes to the [https://ourworldindata.org/grapher/biweekly-growth-covid-cases Our World in Data] site with the most recent data.
* A summary of key findings about [http://www.cdc.gov/coronavirus/2019-nCoV/lab/index.html COVID-19] can be found at [http://www.cdc.gov/ the '''CDC'''].
* A summary of key findings about [http://www.cdc.gov/coronavirus/2019-nCoV/lab/index.html COVID-19] can be found at [http://www.cdc.gov/ the '''CDC'''].

Current revision

Morph showing the transition of SARS-CoV-2 spike protein from its closed to open conformation induced by proteolytic cleavage, details at SARS-CoV-2_spike_protein_priming_by_furin

Drag the structure with the mouse to rotate

References

Retrieved from "http://52.214.119.220/wiki/index.php/Coronavirus_Disease_2019_%28COVID-19%29"
Personal tools