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8bb8
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of human aldehyde dehydrogenase ALDH3A1 in complex with octanal== | |
| - | + | <StructureSection load='8bb8' size='340' side='right'caption='[[8bb8]], [[Resolution|resolution]] 1.80Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8bb8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8BB8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8BB8 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=OYA:OCTANAL'>OYA</scene></td></tr> |
| - | [[Category: Neiers | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8bb8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8bb8 OCA], [https://pdbe.org/8bb8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8bb8 RCSB], [https://www.ebi.ac.uk/pdbsum/8bb8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8bb8 ProSAT]</span></td></tr> |
| - | [[Category: Schwartz | + | </table> |
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/AL3A1_HUMAN AL3A1_HUMAN] ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde. They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation. This protein preferentially oxidizes aromatic aldehyde substrates. It may play a role in the oxidation of toxic aldehydes. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Neiers F]] | ||
| + | [[Category: Schwartz M]] | ||
Current revision
Crystal structure of human aldehyde dehydrogenase ALDH3A1 in complex with octanal
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