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8bo3

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(New page: '''Unreleased structure''' The entry 8bo3 is ON HOLD Authors: Schaefer, M., Roehrig, S., Ackerstaff, J., Nunez, E.J., Gericke, K.M., Meier, K., Tersteegen, A., Stampfuss, J., Ellerbrock...)
Current revision (11:12, 14 March 2024) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 8bo3 is ON HOLD
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==COAGULATION FACTOR XI PROTEASE DOMAIN IN COMPLEX WITH ACTIVE SITE INHIBITOR Asundexian==
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<StructureSection load='8bo3' size='340' side='right'caption='[[8bo3]], [[Resolution|resolution]] 1.84&Aring;' scene=''>
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Authors: Schaefer, M., Roehrig, S., Ackerstaff, J., Nunez, E.J., Gericke, K.M., Meier, K., Tersteegen, A., Stampfuss, J., Ellerbrock, P., Meibom, D., Lang, D., Heitmeier, S., Hillisch, A.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8bo3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8BO3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8BO3 FirstGlance]. <br>
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Description: COAGULATION FACTOR XI PROTEASE DOMAIN IN COMPLEX WITH ACTIVE SITE INHIBITOR Asundexian
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.841&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=QV3:4-[[(2~{S})-2-[4-[5-chloranyl-2-[4-(trifluoromethyl)-1,2,3-triazol-1-yl]phenyl]-5-methoxy-2-oxidanylidene-pyridin-1-yl]butanoyl]amino]-2-fluoranyl-benzamide'>QV3</scene></td></tr>
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[[Category: Ellerbrock, P]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8bo3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8bo3 OCA], [https://pdbe.org/8bo3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8bo3 RCSB], [https://www.ebi.ac.uk/pdbsum/8bo3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8bo3 ProSAT]</span></td></tr>
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[[Category: Hillisch, A]]
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</table>
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[[Category: Gericke, K.M]]
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== Disease ==
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[[Category: Ackerstaff, J]]
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[https://www.uniprot.org/uniprot/FA11_HUMAN FA11_HUMAN] Defects in F11 are the cause of factor XI deficiency (FA11D) [MIM:[https://omim.org/entry/612416 612416]; also known as plasma thromboplastin antecedent deficiency or Rosenthal syndrome. It is a hemorrhagic disease characterized by reduced levels and activity of factor XI resulting in moderate bleeding symptoms, usually occurring after trauma or surgery. Patients usually do not present spontaneous bleeding but women can present with menorrhagia. Hemorrhages are usually moderate.<ref>PMID:2813350</ref> <ref>PMID:1547342</ref> <ref>PMID:7888672</ref> <ref>PMID:7669672</ref> <ref>PMID:9401068</ref> <ref>PMID:9787168</ref> <ref>PMID:10027710</ref> <ref>PMID:10606881</ref> <ref>PMID:11895778</ref> <ref>PMID:15026311</ref> <ref>PMID:15180874</ref> <ref>PMID:15953011</ref> <ref>PMID:16607084</ref> <ref>PMID:18005151</ref> <ref>PMID:21668437</ref> <ref>PMID:21457405</ref> <ref>PMID:22016685</ref> <ref>PMID:22322133</ref> <ref>PMID:21999818</ref> <ref>PMID:22159456</ref>
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[[Category: Nunez, E.J]]
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== Function ==
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[[Category: Heitmeier, S]]
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[https://www.uniprot.org/uniprot/FA11_HUMAN FA11_HUMAN] Factor XI triggers the middle phase of the intrinsic pathway of blood coagulation by activating factor IX.
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[[Category: Meier, K]]
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== References ==
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[[Category: Lang, D]]
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<references/>
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[[Category: Stampfuss, J]]
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__TOC__
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[[Category: Schaefer, M]]
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</StructureSection>
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[[Category: Roehrig, S]]
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[[Category: Homo sapiens]]
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[[Category: Tersteegen, A]]
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[[Category: Large Structures]]
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[[Category: Meibom, D]]
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[[Category: Ackerstaff J]]
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[[Category: Ellerbrock P]]
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[[Category: Gericke KM]]
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[[Category: Heitmeier S]]
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[[Category: Hillisch A]]
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[[Category: Lang D]]
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[[Category: Meibom D]]
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[[Category: Meier K]]
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[[Category: Nunez EJ]]
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[[Category: Roehrig S]]
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[[Category: Schaefer M]]
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[[Category: Stampfuss J]]
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[[Category: Tersteegen A]]

Current revision

COAGULATION FACTOR XI PROTEASE DOMAIN IN COMPLEX WITH ACTIVE SITE INHIBITOR Asundexian

PDB ID 8bo3

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