This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
8d2x
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Zebrafish MFSD2A isoform B in inward open ligand 3C conformation== | |
| - | + | <StructureSection load='8d2x' size='340' side='right'caption='[[8d2x]], [[Resolution|resolution]] 3.40Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8d2x]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Danio_rerio Danio rerio] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8D2X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8D2X FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LMT:DODECYL-BETA-D-MALTOSIDE'>LMT</scene>, <scene name='pdbligand=ZGS:[(2~{R})-2-oxidanyl-3-[oxidanyl-[2-(trimethyl-$l^{4}-azanyl)ethoxy]phosphoryl]oxy-propyl]+(9~{Z},12~{Z},15~{Z})-octadeca-9,12,15-trienoate'>ZGS</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8d2x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8d2x OCA], [https://pdbe.org/8d2x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8d2x RCSB], [https://www.ebi.ac.uk/pdbsum/8d2x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8d2x ProSAT]</span></td></tr> |
| - | [[Category: | + | </table> |
| - | [[Category: | + | == Function == |
| - | [[Category: | + | [https://www.uniprot.org/uniprot/NLS1B_DANRE NLS1B_DANRE] Sodium-dependent lysophosphatidylcholine (LPC) symporter, which plays an essential role for blood-brain barrier formation and function. Specifically expressed in endothelium of the blood-brain barrier of micro-vessels and transports LPC into the brain. Transport of LPC is essential because it constitutes the major mechanism by which docosahexaenoic acid (DHA), an omega-3 fatty acid that is essential for normal brain growth and cognitive function, enters the brain. Transports LPC carrying long-chain fatty acids such LPC oleate and LPC palmitate with a minimum acyl chain length of 14 carbons. Does not transport docosahexaenoic acid in unesterified fatty acid.[UniProtKB:Q9DA75] |
| - | [[Category: Lai | + | __TOC__ |
| - | [[Category: | + | </StructureSection> |
| - | [[Category: | + | [[Category: Danio rerio]] |
| - | [[Category: | + | [[Category: Large Structures]] |
| + | [[Category: Mus musculus]] | ||
| + | [[Category: Gallentino MJ]] | ||
| + | [[Category: Gonen T]] | ||
| + | [[Category: Lai LTF]] | ||
| + | [[Category: Lei HT]] | ||
| + | [[Category: Matthies D]] | ||
| + | [[Category: Mu X]] | ||
| + | [[Category: Nguyen C]] | ||
Current revision
Zebrafish MFSD2A isoform B in inward open ligand 3C conformation
| |||||||||||
Categories: Danio rerio | Large Structures | Mus musculus | Gallentino MJ | Gonen T | Lai LTF | Lei HT | Matthies D | Mu X | Nguyen C
