8etk
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Bile salt hydrolase A from Lactobacillus gasseri bound to covalent probe== | |
| - | + | <StructureSection load='8etk' size='340' side='right'caption='[[8etk]], [[Resolution|resolution]] 1.83Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8etk]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Lactobacillus_gasseri Lactobacillus gasseri]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8ETK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8ETK FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.83Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=WU9:(5~{R})-5-[(3~{R},5~{R},8~{R},9~{S},10~{S},13~{R},14~{S},17~{R})-10,13-dimethyl-3-[2-(2-prop-2-ynoxyethoxy)ethoxy]-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1~{H}-cyclopenta[a]phenanthren-17-yl]-1-fluoranyl-hexan-2-one'>WU9</scene></td></tr> |
| - | [[Category: Grundy | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8etk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8etk OCA], [https://pdbe.org/8etk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8etk RCSB], [https://www.ebi.ac.uk/pdbsum/8etk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8etk ProSAT]</span></td></tr> |
| - | [[Category: | + | </table> |
| - | [[Category: | + | == Function == |
| + | [https://www.uniprot.org/uniprot/CBH_LACGA CBH_LACGA] Bile salt hydrolase that catalyzes the deconjugation of glycine- and taurine-linked bile salts, which occurs naturally in the intestines of humans, releasing amino acid residues and deconjugated bile salts (bile acids) (PubMed:34066735). Can hydrolyze the amide bond in the bile salts taurocholate (TCA), taurodeoxycholate (TDCA), taurochenodeoxycholate (TCDCA), glycocholate (GCA) and glycodeoxycholate (GDCA) (PubMed:34066735). Shows highest activity toward the taurine-conjugated bile salts TCA and TCDCA (PubMed:34066735). The activity toward the other three substrates (TDCA, GCA and GDCA) is relatively low (PubMed:34066735). This enzyme likely contributes to bile salt resistance of the strain and may be associated with survival capability of strain JCM1131 within the human intestine by bile detoxification (PubMed:34066735).<ref>PMID:34066735</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Lactobacillus gasseri]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Grundy MK]] | ||
| + | [[Category: Redinbo MR]] | ||
| + | [[Category: Walker ME]] | ||
Current revision
Bile salt hydrolase A from Lactobacillus gasseri bound to covalent probe
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