1hkf

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(New page: 200px<br /> <applet load="1hkf" size="450" color="white" frame="true" align="right" spinBox="true" caption="1hkf, resolution 2.2&Aring;" /> '''THE THREE DIMENSIONA...)
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[[Image:1hkf.gif|left|200px]]<br />
 
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<applet load="1hkf" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1hkf, resolution 2.2&Aring;" />
 
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'''THE THREE DIMENSIONAL STRUCTURE OF NK CELL RECEPTOR NKP44, A TRIGGERING PARTNER IN NATURAL CYTOTOXICITY'''<br />
 
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==Overview==
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==The three dimensional structure of NK cell receptor Nkp44, a triggering partner in natural cytotoxicity==
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Natural killer (NK) cells direct cytotoxicity against tumor or virally, infected cells. NK cell activation depends on a fine balance between, inhibitory and activating receptors. NKp44 is a cytotoxicity activating, receptor composed of one Ig-like extracellular domain, a transmembrane, segment, and a cytoplasmic domain. The 2.2 A crystal structure shows that, the NKp44 Ig domain forms a saddle-shaped dimer, where a charged surface, groove protrudes from the core structure in each subunit. NKp44 Ig domain, disulfide bridge topology defines a new Ig structural subfamily. The data, presented are a first step toward understanding the molecular basis for, ligand recognition by natural cytotoxicity receptors, whose key role in, the immune system is established, but whose cellular ligands are still, elusive.
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<StructureSection load='1hkf' size='340' side='right'caption='[[1hkf]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1hkf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HKF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1HKF FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1hkf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hkf OCA], [https://pdbe.org/1hkf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1hkf RCSB], [https://www.ebi.ac.uk/pdbsum/1hkf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1hkf ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/NCTR2_HUMAN NCTR2_HUMAN] Cytotoxicity-activating receptor that may contribute to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis.<ref>PMID:10049942</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hk/1hkf_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1hkf ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Natural killer (NK) cells direct cytotoxicity against tumor or virally infected cells. NK cell activation depends on a fine balance between inhibitory and activating receptors. NKp44 is a cytotoxicity activating receptor composed of one Ig-like extracellular domain, a transmembrane segment, and a cytoplasmic domain. The 2.2 A crystal structure shows that the NKp44 Ig domain forms a saddle-shaped dimer, where a charged surface groove protrudes from the core structure in each subunit. NKp44 Ig domain disulfide bridge topology defines a new Ig structural subfamily. The data presented are a first step toward understanding the molecular basis for ligand recognition by natural cytotoxicity receptors, whose key role in the immune system is established, but whose cellular ligands are still elusive.
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==About this Structure==
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The three-dimensional structure of the human NK cell receptor NKp44, a triggering partner in natural cytotoxicity.,Cantoni C, Ponassi M, Biassoni R, Conte R, Spallarossa A, Moretta A, Moretta L, Bolognesi M, Bordo D Structure. 2003 Jun;11(6):725-34. PMID:12791260<ref>PMID:12791260</ref>
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1HKF is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1HKF OCA].
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==Reference==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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The three-dimensional structure of the human NK cell receptor NKp44, a triggering partner in natural cytotoxicity., Cantoni C, Ponassi M, Biassoni R, Conte R, Spallarossa A, Moretta A, Moretta L, Bolognesi M, Bordo D, Structure. 2003 Jun;11(6):725-34. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12791260 12791260]
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</div>
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[[Category: Homo sapiens]]
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<div class="pdbe-citations 1hkf" style="background-color:#fffaf0;"></div>
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[[Category: Single protein]]
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[[Category: Biassoni, R.]]
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[[Category: Bolognesi, M.]]
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[[Category: Bordo, D.]]
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[[Category: Cantoni, C.]]
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[[Category: Conte, R.]]
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[[Category: Moretta, A.]]
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[[Category: Moretta, L.]]
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[[Category: Ponassi, M.]]
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[[Category: Spallarossa, A.]]
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[[Category: immunoglobulin domain]]
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[[Category: natural cytotoxicity receptor]]
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[[Category: nkp44]]
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[[Category: receptor]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 17:19:20 2007''
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==See Also==
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*[[NK cell receptor|NK cell receptor]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Biassoni R]]
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[[Category: Bolognesi M]]
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[[Category: Bordo D]]
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[[Category: Cantoni C]]
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[[Category: Conte R]]
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[[Category: Moretta A]]
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[[Category: Moretta L]]
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[[Category: Ponassi M]]
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[[Category: Spallarossa A]]

Current revision

The three dimensional structure of NK cell receptor Nkp44, a triggering partner in natural cytotoxicity

PDB ID 1hkf

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