8bq1
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Herpes simplex virus type 1 protease== | |
| - | + | <StructureSection load='8bq1' size='340' side='right'caption='[[8bq1]], [[Resolution|resolution]] 2.32Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8bq1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_alphaherpesvirus_1_strain_17 Human alphaherpesvirus 1 strain 17]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8BQ1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8BQ1 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.32Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8bq1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8bq1 OCA], [https://pdbe.org/8bq1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8bq1 RCSB], [https://www.ebi.ac.uk/pdbsum/8bq1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8bq1 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/SCAF_HHV11 SCAF_HHV11] Acts as a scaffold protein by binding major capsid protein in the cytoplasm, inducing the nuclear localization of both proteins. Multimerizes in the nucleus such as major capsid protein forms the icosahedral T=16 capsid. Autocatalytic cleavage releases the assembly protein, and subsequently abolishes interaction with major capsid protein. Cleavages products are evicted from the capsid before or during DNA packaging.[HAMAP-Rule:MF_04008] Protease that plays an essential role in virion assembly within the nucleus. Catalyzes the cleavage of the assembly protein after formation of the spherical procapsid. By that cleavage, the capsid matures and gains its icosahedral shape. The cleavage sites seem to include -Ala-Ser-, -Ala-Ala-, as well as Ala-Thr bonds. Assemblin and cleavages products are evicted from the capsid before or during DNA packaging.[HAMAP-Rule:MF_04008] Plays a major role in capsid assembly. Acts as a scaffold protein by binding major capsid protein. Multimerizes in the nucleus such as major capsid protein forms the icosahedral T=16 capsid. Cleaved by assemblin after capsid completion. The cleavages products are evicted from the capsid before or during DNA packaging.[HAMAP-Rule:MF_04008] | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Human alphaherpesvirus 1 strain 17]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Czarna A]] | ||
| + | [[Category: Grzywa R]] | ||
| + | [[Category: Mackereth C]] | ||
| + | [[Category: Pachota M]] | ||
| + | [[Category: Plewka J]] | ||
| + | [[Category: Pyrc K]] | ||
| + | [[Category: Sienczyk M]] | ||
| + | [[Category: Wilk P]] | ||
Current revision
Herpes simplex virus type 1 protease
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