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8f7s
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 8f7s is ON HOLD Authors: Wang, Y., Zhuang, Y., DiBerto, J.F., Zhou, X.E., Schmitz, G.P., Yuan, Q., Jain, M.K., Liu, W., Melcher, K., Jiang, Y., Roth...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Gi bound delta-opioid receptor in complex with deltorphin== | |
| - | + | <StructureSection load='8f7s' size='340' side='right'caption='[[8f7s]], [[Resolution|resolution]] 3.00Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8f7s]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus], [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens], [https://en.wikipedia.org/wiki/Phyllomedusa Phyllomedusa] and [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8F7S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8F7S FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene>, <scene name='pdbligand=DAL:D-ALANINE'>DAL</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene>, <scene name='pdbligand=PLM:PALMITIC+ACID'>PLM</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8f7s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8f7s OCA], [https://pdbe.org/8f7s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8f7s RCSB], [https://www.ebi.ac.uk/pdbsum/8f7s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8f7s ProSAT]</span></td></tr> |
| - | [[Category: | + | </table> |
| - | [[Category: | + | == Function == |
| - | [[Category: Jain | + | [https://www.uniprot.org/uniprot/OPRD_HUMAN OPRD_HUMAN] G-protein coupled receptor that functions as receptor for endogenous enkephalins and for a subset of other opioids. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain and in opiate-mediated analgesia. Plays a role in developing analgesic tolerance to morphine.<ref>PMID:22184124</ref> <ref>PMID:7808419</ref> <ref>PMID:8201839</ref> |
| - | [[Category: | + | == References == |
| - | [[Category: Liu | + | <references/> |
| - | [[Category: | + | __TOC__ |
| - | [[Category: | + | </StructureSection> |
| - | [[Category: | + | [[Category: Bos taurus]] |
| - | [[Category: | + | [[Category: Homo sapiens]] |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: Yuan | + | [[Category: Phyllomedusa]] |
| - | [[Category: | + | [[Category: Rattus norvegicus]] |
| + | [[Category: DiBerto JF]] | ||
| + | [[Category: Jain MK]] | ||
| + | [[Category: Jiang Y]] | ||
| + | [[Category: Liu W]] | ||
| + | [[Category: Melcher K]] | ||
| + | [[Category: Roth BL]] | ||
| + | [[Category: Schmitz GP]] | ||
| + | [[Category: Wang Y]] | ||
| + | [[Category: Xu HE]] | ||
| + | [[Category: Yuan Q]] | ||
| + | [[Category: Zhou XE]] | ||
| + | [[Category: Zhuang Y]] | ||
Current revision
Gi bound delta-opioid receptor in complex with deltorphin
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Categories: Bos taurus | Homo sapiens | Large Structures | Phyllomedusa | Rattus norvegicus | DiBerto JF | Jain MK | Jiang Y | Liu W | Melcher K | Roth BL | Schmitz GP | Wang Y | Xu HE | Yuan Q | Zhou XE | Zhuang Y
