This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
8bbs
From Proteopedia
(Difference between revisions)
| (One intermediate revision not shown.) | |||
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Structure of AKR1C3 in complex with a bile acid fused tetrazole inhibitor== | |
| + | <StructureSection load='8bbs' size='340' side='right'caption='[[8bbs]], [[Resolution|resolution]] 1.40Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[8bbs]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8BBS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8BBS FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.4Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=QBO:(4~{R})-4-[(1~{R},2~{S},5~{R},6~{R},13~{S},14~{S},17~{R},19~{R})-6,14-dimethyl-17-oxidanyl-7,8,9,10-tetrazapentacyclo[11.8.0.0^{2,6}.0^{7,11}.0^{14,19}]henicosa-8,10-dien-5-yl]pentanoic+acid'>QBO</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8bbs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8bbs OCA], [https://pdbe.org/8bbs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8bbs RCSB], [https://www.ebi.ac.uk/pdbsum/8bbs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8bbs ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/AK1C3_HUMAN AK1C3_HUMAN] Catalyzes the conversion of aldehydes and ketones to alcohols. Catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ) and the oxidation of 9-alpha,11-beta-PGF2 to PGD2. Functions as a bi-directional 3-alpha-, 17-beta- and 20-alpha HSD. Can interconvert active androgens, estrogens and progestins with their cognate inactive metabolites. Preferentially transforms androstenedione (4-dione) to testosterone. | ||
| - | + | ==See Also== | |
| - | + | *[[Prostaglandin F synthase 3D structures|Prostaglandin F synthase 3D structures]] | |
| - | + | __TOC__ | |
| - | [[Category: | + | </StructureSection> |
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Bekic S]] | ||
| + | [[Category: Brynda J]] | ||
| + | [[Category: Celic AS]] | ||
| + | [[Category: Kugler M]] | ||
| + | [[Category: Marinovic M]] | ||
| + | [[Category: Petri ET]] | ||
| + | [[Category: Rezacova P]] | ||
| + | [[Category: Skerlova J]] | ||
| + | [[Category: Skoric D]] | ||
Current revision
Structure of AKR1C3 in complex with a bile acid fused tetrazole inhibitor
| |||||||||||
Categories: Homo sapiens | Large Structures | Bekic S | Brynda J | Celic AS | Kugler M | Marinovic M | Petri ET | Rezacova P | Skerlova J | Skoric D
