8bbs
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Structure of AKR1C3 in complex with a bile acid fused tetrazole inhibitor== | |
| + | <StructureSection load='8bbs' size='340' side='right'caption='[[8bbs]], [[Resolution|resolution]] 1.40Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[8bbs]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8BBS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8BBS FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.4Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=QBO:(4~{R})-4-[(1~{R},2~{S},5~{R},6~{R},13~{S},14~{S},17~{R},19~{R})-6,14-dimethyl-17-oxidanyl-7,8,9,10-tetrazapentacyclo[11.8.0.0^{2,6}.0^{7,11}.0^{14,19}]henicosa-8,10-dien-5-yl]pentanoic+acid'>QBO</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8bbs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8bbs OCA], [https://pdbe.org/8bbs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8bbs RCSB], [https://www.ebi.ac.uk/pdbsum/8bbs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8bbs ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/AK1C3_HUMAN AK1C3_HUMAN] Catalyzes the conversion of aldehydes and ketones to alcohols. Catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ) and the oxidation of 9-alpha,11-beta-PGF2 to PGD2. Functions as a bi-directional 3-alpha-, 17-beta- and 20-alpha HSD. Can interconvert active androgens, estrogens and progestins with their cognate inactive metabolites. Preferentially transforms androstenedione (4-dione) to testosterone. | ||
| - | + | ==See Also== | |
| - | + | *[[Prostaglandin F synthase 3D structures|Prostaglandin F synthase 3D structures]] | |
| - | + | __TOC__ | |
| - | [[Category: | + | </StructureSection> |
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Bekic S]] | ||
| + | [[Category: Brynda J]] | ||
| + | [[Category: Celic AS]] | ||
| + | [[Category: Kugler M]] | ||
| + | [[Category: Marinovic M]] | ||
| + | [[Category: Petri ET]] | ||
| + | [[Category: Rezacova P]] | ||
| + | [[Category: Skerlova J]] | ||
| + | [[Category: Skoric D]] | ||
Current revision
Structure of AKR1C3 in complex with a bile acid fused tetrazole inhibitor
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Categories: Homo sapiens | Large Structures | Bekic S | Brynda J | Celic AS | Kugler M | Marinovic M | Petri ET | Rezacova P | Skerlova J | Skoric D
