8ez6

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Current revision (10:07, 27 March 2024) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 8ez6 is ON HOLD until Paper Publication
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==The DBC1/SIRT1 Interaction is Choreographed by Post-translational Modification==
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<StructureSection load='8ez6' size='340' side='right'caption='[[8ez6]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8ez6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8EZ6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8EZ6 FirstGlance]. <br>
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Description:
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8ez6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8ez6 OCA], [https://pdbe.org/8ez6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8ez6 RCSB], [https://www.ebi.ac.uk/pdbsum/8ez6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8ez6 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CCAR2_HUMAN CCAR2_HUMAN] Core component of the DBIRD complex, a multiprotein complex that acts at the interface between core mRNP particles and RNA polymerase II (RNAPII) and integrates transcript elongation with the regulation of alternative splicing: the DBIRD complex affects local transcript elongation rates and alternative splicing of a large set of exons embedded in (A + T)-rich DNA regions (PubMed:22446626). Inhibits SIRT1 deacetylase activity leading to increasing levels of p53/TP53 acetylation and p53-mediated apoptosis (PubMed:18235501, PubMed:18235502, PubMed:23352644). Inhibits SUV39H1 methyltransferase activity (PubMed:19218236). Mediates ligand-dependent transcriptional activation by nuclear hormone receptors (PubMed:19131338). Plays a critical role in maintaining genomic stability and cellular integrity following UV-induced genotoxic stress (PubMed:23398316). Regulates the circadian expression of the core clock components NR1D1 and BMAL1 (PubMed:23398316). Enhances the transcriptional repressor activity of NR1D1 through stabilization of NR1D1 protein levels by preventing its ubiquitination and subsequent degradation (PubMed:23398316). Represses the ligand-dependent transcriptional activation function of ESR2 (PubMed:20074560). Acts as a regulator of PCK1 expression and gluconeogenesis by a mechanism that involves, at least in part, both NR1D1 and SIRT1 (PubMed:24415752). Negatively regulates the deacetylase activity of HDAC3 and can alter its subcellular localization (PubMed:21030595). Positively regulates the beta-catenin pathway (canonical Wnt signaling pathway) and is required for MCC-mediated repression of the beta-catenin pathway (PubMed:24824780). Represses ligand-dependent transcriptional activation function of NR1H2 and NR1H3 and inhibits the interaction of SIRT1 with NR1H3 (PubMed:25661920). Plays an important role in tumor suppression through p53/TP53 regulation; stabilizes p53/TP53 by affecting its interaction with ubiquitin ligase MDM2 (PubMed:25732823). Represses the transcriptional activator activity of BRCA1 (PubMed:20160719). Inhibits SIRT1 in a CHEK2 and PSEM3-dependent manner and inhibits the activity of CHEK2 in vitro (PubMed:25361978).<ref>PMID:18235501</ref> <ref>PMID:18235502</ref> <ref>PMID:19131338</ref> <ref>PMID:19218236</ref> <ref>PMID:20074560</ref> <ref>PMID:20160719</ref> <ref>PMID:21030595</ref> <ref>PMID:22446626</ref> <ref>PMID:23352644</ref> <ref>PMID:23398316</ref> <ref>PMID:24415752</ref> <ref>PMID:24824780</ref> <ref>PMID:25361978</ref> <ref>PMID:25661920</ref> <ref>PMID:25732823</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Gronenborn AM]]
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[[Category: Kim YJ]]
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[[Category: Krzysiak TC]]
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[[Category: Thomas G]]

Current revision

The DBC1/SIRT1 Interaction is Choreographed by Post-translational Modification

PDB ID 8ez6

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