This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
8fbh
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 8fbh is ON HOLD Authors: Providokhina, K., Dong, A., Arrowsmith, C.H., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC) Description: Cr...) |
|||
| (2 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of NSD1 Mutant-T1927A== | |
| - | + | <StructureSection load='8fbh' size='340' side='right'caption='[[8fbh]], [[Resolution|resolution]] 2.32Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8fbh]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8FBH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8FBH FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.32Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8fbh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8fbh OCA], [https://pdbe.org/8fbh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8fbh RCSB], [https://www.ebi.ac.uk/pdbsum/8fbh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8fbh ProSAT]</span></td></tr> |
| - | [[Category: | + | </table> |
| - | [[Category: | + | == Function == |
| - | [[Category: | + | [https://www.uniprot.org/uniprot/NSD1_MOUSE NSD1_MOUSE] Histone methyltransferase. Preferentially methylates 'Lys-36' of histone H3 and 'Lys-20' of histone H4 (in vitro). Transcriptional intermediary factor capable of negatively influencing transcription. May also positively influence transcription. Essential for early post-implantation development.<ref>PMID:12805229</ref> <ref>PMID:9628876</ref> |
| - | [[Category: | + | == References == |
| - | [[Category: Providokhina | + | <references/> |
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Mus musculus]] | ||
| + | [[Category: Arrowsmith CH]] | ||
| + | [[Category: Dong A]] | ||
| + | [[Category: Edwards AM]] | ||
| + | [[Category: Min J]] | ||
| + | [[Category: Providokhina K]] | ||
Current revision
Crystal structure of NSD1 Mutant-T1927A
| |||||||||||
